Abstract
The authors screened for tau gene mutations and polymorphisms to determine whether genetic variation at or near the tau locus contributes to the development of primary progressive aphasia (PPA). No mutations were detected in 25 patients with PPA. However, a significant overrepresentation of the tau H1/H1 genotype, also found in progressive supranuclear palsy and corticobasal degeneration, was found in the PPA group. Whether tau haplotypes have a primary causal role or whether they affect the topology of neurodegeneration remains to be determined.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 862-864 |
| Number of pages | 3 |
| Journal | Neurology |
| Volume | 60 |
| Issue number | 5 |
| State | Published - Mar 11 2003 |
Fingerprint
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Possible association of the tau H1/H1 genotype with primary progressive aphasia. / Sobrido, M. J.; Abu-Khalil, A.; Weintraub, S.; Johnson, N.; Quinn, B.; Cummings, J. L.; Mesulam, M. M.; Geschwind, Daniel H.
In: Neurology, Vol. 60, No. 5, 11.03.2003, p. 862-864.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Possible association of the tau H1/H1 genotype with primary progressive aphasia
AU - Sobrido, M. J.
AU - Abu-Khalil, A.
AU - Weintraub, S.
AU - Johnson, N.
AU - Quinn, B.
AU - Cummings, J. L.
AU - Mesulam, M. M.
AU - Geschwind, Daniel H.
PY - 2003/3/11
Y1 - 2003/3/11
N2 - The authors screened for tau gene mutations and polymorphisms to determine whether genetic variation at or near the tau locus contributes to the development of primary progressive aphasia (PPA). No mutations were detected in 25 patients with PPA. However, a significant overrepresentation of the tau H1/H1 genotype, also found in progressive supranuclear palsy and corticobasal degeneration, was found in the PPA group. Whether tau haplotypes have a primary causal role or whether they affect the topology of neurodegeneration remains to be determined.
AB - The authors screened for tau gene mutations and polymorphisms to determine whether genetic variation at or near the tau locus contributes to the development of primary progressive aphasia (PPA). No mutations were detected in 25 patients with PPA. However, a significant overrepresentation of the tau H1/H1 genotype, also found in progressive supranuclear palsy and corticobasal degeneration, was found in the PPA group. Whether tau haplotypes have a primary causal role or whether they affect the topology of neurodegeneration remains to be determined.
UR - http://www.scopus.com/inward/record.url?scp=0037432268&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037432268&partnerID=8YFLogxK
M3 - Article
C2 - 12629248
AN - SCOPUS:0037432268
VL - 60
SP - 862
EP - 864
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 5
ER -