Positron emission tomography–CT prediction of occult nodal metastasis in recurrent laryngeal cancer

Andrew Rosko, Andrew Birkeland, Andrew Shuman, Mark Prince, Carol Bradford, Gregory Wolf, Francis Worden, Avraham Eisbruch, Ashok Srinivasan, Ka Kit Wong, Matthew E. Spector

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Background: The purpose of this study was to evaluate the predictive value of positron emission tomography (PET)-CT in identifying occult nodal metastasis in clinically and radiographically N0 patients with recurrent laryngeal cancer undergoing salvage laryngectomy. Methods: Retrospective review of 46 clinically and radiographically N0 patients with recurrent laryngeal cancer who underwent a PET-CT examination before salvage laryngectomy with neck dissection from January 1, 2002, to December 31, 2014, was performed. Results: Two patients (16.7%) had true-positive PET-CT results, whereas 10 patients (83.3%) had false-negative scans, 1 patient (2.9%) had a false-positive result and 33 patients (97.1%) had a true-negative PET-CT. The sensitivity of PET-CT was 16.7% (95% confidence interval [CI], 3.5% to 46.0%) with a specificity of 97.1% (95% CI, 83.8% to 99.9%), positive predictive value (PPV) of 66.7% (95% CI, 20.2% to 94.4%), and negative predictive value (NPV) of 76.7% (95% CI, 62.1% to 87.0%). Conclusion: PET-CT has poor sensitivity and NPV making PET-CT an imperfect predictor of nodal disease in recurrent laryngeal cancer.

Original languageEnglish (US)
Pages (from-to)980-987
Number of pages8
JournalHead and Neck
Volume39
Issue number5
DOIs
StatePublished - May 2017
Externally publishedYes

Keywords

  • laryngeal squamous cell carcinoma
  • occult nodal metastasis
  • positron emission tomography (PET)-CT
  • recurrent laryngeal cancer
  • salvage laryngectomy

ASJC Scopus subject areas

  • Otorhinolaryngology

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    Rosko, A., Birkeland, A., Shuman, A., Prince, M., Bradford, C., Wolf, G., Worden, F., Eisbruch, A., Srinivasan, A., Wong, K. K., & Spector, M. E. (2017). Positron emission tomography–CT prediction of occult nodal metastasis in recurrent laryngeal cancer. Head and Neck, 39(5), 980-987. https://doi.org/10.1002/hed.24719