Positron emission tomographic studies of cerebral benzodiazepine- receptor binding in chronic alcoholics

Sid Gilman, Robert A. Koeppe, Kenneth Adams, Douglas Johnson-Greene, Larry Junck, Karen J. Kluin, James A Brunberg, Susan Martorello, Mary Lohman

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Positron emission tomography was used with [ 11C]flumazenil (FMZ) and [ 18F]fluorodeoxyglucose to study GABA type A/benzodiazepine (GABA-A/BDZ) receptors and cerebral metabolic rates for glucose (ICMRglc) in 17 male patients with severe chronic alcoholism (ALC), 8 with (ACD) and 9 without alcoholic cerebellar degeneration (non-ACD). In comparison with male normal controls of similar ages, the ALC group had significantly reduced FMZ ligand influx (K 1), FMZ distribution volume (DV), and ICMRglc bilaterally in the medial frontal lobes, including superior frontal gyrus and rostral cingulate gyrus; the ACD group had significant reductions of K 1, DV, and ICMRglc bilaterally in the same distribution, and also in the superior cerebellar vermis; and the non-ACD group had significant reductions of K 1, DV, and ICMRglc bilaterally in the same regions of the frontal lobes but not in the superior cerebellar vermis. When compared with the non-ACD group, the ACD group had significant reductions of K 1 and DV bilaterally in the superior cerebellar vermis. The results suggest that severe chronic alcoholism damages neurons containing GABA-A/BDZ receptors in the superior medial aspects of the frontal lobes, and in patients with clinical signs of ACD, neurons containing GABA-A/BDZ receptors in the superior cerebellar vermis.

Original languageEnglish (US)
Pages (from-to)163-171
Number of pages9
JournalAnnals of Neurology
Volume40
Issue number2
StatePublished - Aug 1996
Externally publishedYes

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GABA-A Receptors
Alcoholics
Electrons
Flumazenil
Frontal Lobe
Alcoholism
Neurons
Gyrus Cinguli
Fluorodeoxyglucose F18
Prefrontal Cortex
Positron-Emission Tomography
Age Groups
Ligands
Glucose
Cerebellar Vermis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Gilman, S., Koeppe, R. A., Adams, K., Johnson-Greene, D., Junck, L., Kluin, K. J., ... Lohman, M. (1996). Positron emission tomographic studies of cerebral benzodiazepine- receptor binding in chronic alcoholics. Annals of Neurology, 40(2), 163-171.

Positron emission tomographic studies of cerebral benzodiazepine- receptor binding in chronic alcoholics. / Gilman, Sid; Koeppe, Robert A.; Adams, Kenneth; Johnson-Greene, Douglas; Junck, Larry; Kluin, Karen J.; Brunberg, James A; Martorello, Susan; Lohman, Mary.

In: Annals of Neurology, Vol. 40, No. 2, 08.1996, p. 163-171.

Research output: Contribution to journalArticle

Gilman, S, Koeppe, RA, Adams, K, Johnson-Greene, D, Junck, L, Kluin, KJ, Brunberg, JA, Martorello, S & Lohman, M 1996, 'Positron emission tomographic studies of cerebral benzodiazepine- receptor binding in chronic alcoholics', Annals of Neurology, vol. 40, no. 2, pp. 163-171.
Gilman S, Koeppe RA, Adams K, Johnson-Greene D, Junck L, Kluin KJ et al. Positron emission tomographic studies of cerebral benzodiazepine- receptor binding in chronic alcoholics. Annals of Neurology. 1996 Aug;40(2):163-171.
Gilman, Sid ; Koeppe, Robert A. ; Adams, Kenneth ; Johnson-Greene, Douglas ; Junck, Larry ; Kluin, Karen J. ; Brunberg, James A ; Martorello, Susan ; Lohman, Mary. / Positron emission tomographic studies of cerebral benzodiazepine- receptor binding in chronic alcoholics. In: Annals of Neurology. 1996 ; Vol. 40, No. 2. pp. 163-171.
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