Abstract
Positron emission tomography was used with [ 11C]flumazenil (FMZ) and [ 18F]fluorodeoxyglucose to study GABA type A/benzodiazepine (GABA-A/BDZ) receptors and cerebral metabolic rates for glucose (ICMRglc) in 17 male patients with severe chronic alcoholism (ALC), 8 with (ACD) and 9 without alcoholic cerebellar degeneration (non-ACD). In comparison with male normal controls of similar ages, the ALC group had significantly reduced FMZ ligand influx (K 1), FMZ distribution volume (DV), and ICMRglc bilaterally in the medial frontal lobes, including superior frontal gyrus and rostral cingulate gyrus; the ACD group had significant reductions of K 1, DV, and ICMRglc bilaterally in the same distribution, and also in the superior cerebellar vermis; and the non-ACD group had significant reductions of K 1, DV, and ICMRglc bilaterally in the same regions of the frontal lobes but not in the superior cerebellar vermis. When compared with the non-ACD group, the ACD group had significant reductions of K 1 and DV bilaterally in the superior cerebellar vermis. The results suggest that severe chronic alcoholism damages neurons containing GABA-A/BDZ receptors in the superior medial aspects of the frontal lobes, and in patients with clinical signs of ACD, neurons containing GABA-A/BDZ receptors in the superior cerebellar vermis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 163-171 |
| Number of pages | 9 |
| Journal | Annals of Neurology |
| Volume | 40 |
| Issue number | 2 |
| State | Published - Aug 1996 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Positron emission tomographic studies of cerebral benzodiazepine- receptor binding in chronic alcoholics. / Gilman, Sid; Koeppe, Robert A.; Adams, Kenneth; Johnson-Greene, Douglas; Junck, Larry; Kluin, Karen J.; Brunberg, James A; Martorello, Susan; Lohman, Mary.
In: Annals of Neurology, Vol. 40, No. 2, 08.1996, p. 163-171.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Positron emission tomographic studies of cerebral benzodiazepine- receptor binding in chronic alcoholics
AU - Gilman, Sid
AU - Koeppe, Robert A.
AU - Adams, Kenneth
AU - Johnson-Greene, Douglas
AU - Junck, Larry
AU - Kluin, Karen J.
AU - Brunberg, James A
AU - Martorello, Susan
AU - Lohman, Mary
PY - 1996/8
Y1 - 1996/8
N2 - Positron emission tomography was used with [ 11C]flumazenil (FMZ) and [ 18F]fluorodeoxyglucose to study GABA type A/benzodiazepine (GABA-A/BDZ) receptors and cerebral metabolic rates for glucose (ICMRglc) in 17 male patients with severe chronic alcoholism (ALC), 8 with (ACD) and 9 without alcoholic cerebellar degeneration (non-ACD). In comparison with male normal controls of similar ages, the ALC group had significantly reduced FMZ ligand influx (K 1), FMZ distribution volume (DV), and ICMRglc bilaterally in the medial frontal lobes, including superior frontal gyrus and rostral cingulate gyrus; the ACD group had significant reductions of K 1, DV, and ICMRglc bilaterally in the same distribution, and also in the superior cerebellar vermis; and the non-ACD group had significant reductions of K 1, DV, and ICMRglc bilaterally in the same regions of the frontal lobes but not in the superior cerebellar vermis. When compared with the non-ACD group, the ACD group had significant reductions of K 1 and DV bilaterally in the superior cerebellar vermis. The results suggest that severe chronic alcoholism damages neurons containing GABA-A/BDZ receptors in the superior medial aspects of the frontal lobes, and in patients with clinical signs of ACD, neurons containing GABA-A/BDZ receptors in the superior cerebellar vermis.
AB - Positron emission tomography was used with [ 11C]flumazenil (FMZ) and [ 18F]fluorodeoxyglucose to study GABA type A/benzodiazepine (GABA-A/BDZ) receptors and cerebral metabolic rates for glucose (ICMRglc) in 17 male patients with severe chronic alcoholism (ALC), 8 with (ACD) and 9 without alcoholic cerebellar degeneration (non-ACD). In comparison with male normal controls of similar ages, the ALC group had significantly reduced FMZ ligand influx (K 1), FMZ distribution volume (DV), and ICMRglc bilaterally in the medial frontal lobes, including superior frontal gyrus and rostral cingulate gyrus; the ACD group had significant reductions of K 1, DV, and ICMRglc bilaterally in the same distribution, and also in the superior cerebellar vermis; and the non-ACD group had significant reductions of K 1, DV, and ICMRglc bilaterally in the same regions of the frontal lobes but not in the superior cerebellar vermis. When compared with the non-ACD group, the ACD group had significant reductions of K 1 and DV bilaterally in the superior cerebellar vermis. The results suggest that severe chronic alcoholism damages neurons containing GABA-A/BDZ receptors in the superior medial aspects of the frontal lobes, and in patients with clinical signs of ACD, neurons containing GABA-A/BDZ receptors in the superior cerebellar vermis.
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M3 - Article
VL - 40
SP - 163
EP - 171
JO - Annals of Neurology
JF - Annals of Neurology
SN - 0364-5134
IS - 2
ER -