Positive cooperativity among insecticidal scorpion neurotoxins

Rafael Herrmann, Haim Moskowitz, Eliahu Zlotkin, Bruce D. Hammock

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


The insecticidal activity of scorpion neurotoxic polypeptides increased 5-10-fold with no apparent increase in mammalian toxicity when a combination of two toxins was injected. Synergistic combinations could be predicted from binding studies and competitive displacement assays. Our results indicate that simultaneous expression in baculovirus or other transgenic organisms of the synergistic combinations of insecticidal toxins may result in more potent insect-selective biopesticides.

Original languageEnglish (US)
Pages (from-to)1099-1102
Number of pages4
Issue number8
StatePublished - 1995

ASJC Scopus subject areas

  • Toxicology


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