Positive auto-antibody activity with retina and optic nerve in smokers and non-smokers: The controversy continues

Eric K. Chin, David R P Almeida, Khoa V. Lam, John L Keltner, Charles E. Thirkill

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Auto-antibodies assist with the diagnosis of ocular paraneoplastic syndromes and autoimmune ocular conditions; however, the frequency of positive test results as a possible precursor to future disease is unknown. The frequency of positive antibodies in heavy smokers who may be at risk for autoimmune-related retinopathy and optic neuropathy was evaluated. Serum antibody activity was evaluated through the use of Western blot reactions from pig retina and optic nerve extract. Fifty-one patients were included: 35 patients were smokers (average: 40.9 pack-year history) and 26 patients had no past smoking history. None of the patients had any visual complaints or known eye disease. Of the patients studied, 76.5% (39 patients: 18 smokers, 21 non-smokers) had positive antiretinal antibodies, and 19.6% (10 patients: 3 smokers, 7 non-smokers) had positive antioptic nerve antibodies. Anti-retinal antibodies were seen in a majority of randomly selected patients with and without a past smoking history. Anti-optic nerve bodies were less common, but more prevalent in those who never smoked. The specificity of these antibodies remains greatly uncertain and clinical correlation is warranted.

Original languageEnglish (US)
Pages (from-to)1068-1070
Number of pages3
JournalOphthalmic Surgery Lasers and Imaging Retina
Volume46
Issue number10
DOIs
StatePublished - Nov 1 2015

ASJC Scopus subject areas

  • Ophthalmology
  • Surgery
  • Medicine(all)

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