Porphyrin-Based Nanomedicines for Cancer Treatment

Xiangdong Xue, Aaron Lindstrom, Yuanpei Li

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

As unique molecules with both therapeutic and diagnostic properties, porphyrin derivatives have been extensively employed for cancer treatment. Porphyrins not only show powerful phototherapeutic effects (photodynamic and photothermal therapies), but also exhibit excellent imaging capacities, such as near-infrared fluorescent imaging (NIRFI), magnetic resonance imaging (MRI), photoacoustic imaging (PAI), positron emission tomography (PET), and single-photon emission computed tomography (SPECT). In order to take advantage of their robust phototherapeutic effects and excellent imaging capacities, porphyrins can be used to create nanomedicines with effective therapeutic and precise diagnostic properties for cancer treatment. In this Review, we summarize porphyrin-based nanomedicines which have been developed recently, including porphyrin-based liposomes, micelles, polymeric nanoparticles, peptide nanoparticles, and small-molecule nanoassemblies, and their applications on cancer therapy and diagnosis. The outlook and limitation of porphyrin-based nanomedicines are also reviewed.

Original languageEnglish (US)
Pages (from-to)1585-1603
Number of pages19
JournalBioconjugate Chemistry
Volume30
Issue number6
DOIs
StatePublished - Jun 19 2019

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Nanomedicine
Medical nanotechnology
Oncology
Porphyrins
Imaging techniques
Neoplasms
Nanoparticles
Therapeutics
Single photon emission computed tomography
Molecules
Positron emission tomography
Photoacoustic effect
Liposomes
Photochemotherapy
Micelles
Magnetic resonance
Single-Photon Emission-Computed Tomography
Positron-Emission Tomography
Peptides
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

Cite this

Porphyrin-Based Nanomedicines for Cancer Treatment. / Xue, Xiangdong; Lindstrom, Aaron; Li, Yuanpei.

In: Bioconjugate Chemistry, Vol. 30, No. 6, 19.06.2019, p. 1585-1603.

Research output: Contribution to journalArticle

Xue, Xiangdong ; Lindstrom, Aaron ; Li, Yuanpei. / Porphyrin-Based Nanomedicines for Cancer Treatment. In: Bioconjugate Chemistry. 2019 ; Vol. 30, No. 6. pp. 1585-1603.
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