Porcine urinary bladder extracellular matrix grafts (ACell Vet® Corneal Discs) for keratomalacia in 17 equids (2012-2013)

Laura A. Mancuso, Mary Utter, Nicole M. Scherrer

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: To describe the clinical course, outcomes, and complications associated with use of commercially available porcine urinary bladder extracellular matrix (ECM) grafts (ACell Vet® Corneal Discs) in equid patients with keratomalacia, and to evaluate the efficacy of ECM grafts as a viable alternative to other biomaterials for corneal grafting in equid patients. Animals: Sixteen horses and one donkey (17 eyes) with unilateral keratomalacia severe enough to warrant surgical repair between August 2012 and September 2013. Procedure: Retrospective medical record review to identify equid patients meeting inclusion criteria of (i) diagnosis with keratomalacia severe enough to warrant surgical repair and (ii) surgical repair with an extracellular matrix graft. Results: Eleven geldings, four mares, and two colts met inclusion criteria. Patients averaged 9 years of age. Twelve of 17 eyes (71%) were considered infected based on either corneal cytology (10/17, or 59%) or corneal culture (12/17, or 71%) positive for bacteria (8/17, or 47%) or fungi (9/17, or 53%). At the time topical medications were discontinued, 16 eyes (94%) were visual. One operated eye ruptured 5 days postoperatively and was enucleated. Keratouveitis developed in 14/14 eyes that underwent regular examinations approximately 2 weeks postoperatively which responded to systemic nonsteroidal anti-inflammatory drug therapy. Conclusions: Extracellular matrix grafts may be a viable alternative to other biomaterials for corneal grafting in equids. Advantages include commercial availability and shelf storage.

Original languageEnglish (US)
Pages (from-to)3-10
Number of pages8
JournalVeterinary Ophthalmology
Volume19
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

bladder
extracellular matrix
Extracellular Matrix
Urinary Bladder
Swine
eyes
Transplants
swine
biocompatible materials
Corneal Transplantation
Biocompatible Materials
drug therapy
colts
geldings
Equidae
nonsteroidal anti-inflammatory agents
asses
disease course
cell biology
mares

Keywords

  • Equine
  • Extracellular matrix
  • Graft
  • Keratitis
  • Ulcer

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Porcine urinary bladder extracellular matrix grafts (ACell Vet® Corneal Discs) for keratomalacia in 17 equids (2012-2013). / Mancuso, Laura A.; Utter, Mary; Scherrer, Nicole M.

In: Veterinary Ophthalmology, Vol. 19, No. 1, 01.01.2016, p. 3-10.

Research output: Contribution to journalArticle

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