Population structure and antimicrobial resistance of canine uropathogenic Escherichia coli

Tessa E. LeCuyer, Barbara A Byrne, Joshua B. Daniels, Dubraska V. Diaz-Campos, G. Kenitra Hammac, Claire B. Miller, Thomas E. Besser, Margaret A. Davis

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Escherichia coli is the most common cause of human and canine urinary tract infection (UTI). Clonal groups, often with high levels of antimicrobial resistance, are a major component of the E. coli population that causes human UTI. While little is known about the population structure of E. coli that causes UTI in dogs, there is evidence that dogs and humans can share fecal strains of E. coli and that human-associated strains can cause disease in dogs. In order to better characterize the E. coli strains that cause canine UTI, we analyzed 295 E. coli isolates obtained from canine urine samples from five veterinary diagnostic laboratories and analyzed their multilocus sequence types, phenotypic and genotypic antimicrobial resistance profiles, and virulence-associated gene repertoires. Sequence type 372 (ST372), an infrequent human pathogen, was the predominant sequence type in dogs at all locations. Extended-spectrum -lactamase-producing isolates with blaCTX-M genes were uncommon in canine isolates but when present were often associated with sequence types that have been described in human infections. This provides support for occasional cross-host-species sharing of strains that cause extraintestinal disease and highlights the importance of understanding the role of companion animals in the overall transmission patterns of extraintestinal pathogenic E. coli.

Original languageEnglish (US)
Article numbere00788
JournalJournal of Clinical Microbiology
Volume56
Issue number9
DOIs
StatePublished - Sep 1 2018
Externally publishedYes

Fingerprint

Uropathogenic Escherichia coli
Canidae
Escherichia coli
Urinary Tract Infections
Population
Dogs
Dog Diseases
Pets
Genes
Virulence
Urine
Infection

Keywords

  • Canine
  • Escherichia coli
  • Molecular epidemiology
  • Urinary tract infection
  • Veterinary microbiology

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

LeCuyer, T. E., Byrne, B. A., Daniels, J. B., Diaz-Campos, D. V., Hammac, G. K., Miller, C. B., ... Davis, M. A. (2018). Population structure and antimicrobial resistance of canine uropathogenic Escherichia coli. Journal of Clinical Microbiology, 56(9), [e00788]. https://doi.org/10.1128/JCM.00788-18

Population structure and antimicrobial resistance of canine uropathogenic Escherichia coli. / LeCuyer, Tessa E.; Byrne, Barbara A; Daniels, Joshua B.; Diaz-Campos, Dubraska V.; Hammac, G. Kenitra; Miller, Claire B.; Besser, Thomas E.; Davis, Margaret A.

In: Journal of Clinical Microbiology, Vol. 56, No. 9, e00788, 01.09.2018.

Research output: Contribution to journalArticle

LeCuyer, TE, Byrne, BA, Daniels, JB, Diaz-Campos, DV, Hammac, GK, Miller, CB, Besser, TE & Davis, MA 2018, 'Population structure and antimicrobial resistance of canine uropathogenic Escherichia coli', Journal of Clinical Microbiology, vol. 56, no. 9, e00788. https://doi.org/10.1128/JCM.00788-18
LeCuyer, Tessa E. ; Byrne, Barbara A ; Daniels, Joshua B. ; Diaz-Campos, Dubraska V. ; Hammac, G. Kenitra ; Miller, Claire B. ; Besser, Thomas E. ; Davis, Margaret A. / Population structure and antimicrobial resistance of canine uropathogenic Escherichia coli. In: Journal of Clinical Microbiology. 2018 ; Vol. 56, No. 9.
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