Population-based case-control study of soyfood intake and breast cancer risk in Shanghai

Q. Dai, X. O. Shu, F. Jin, J. D. Potter, L. H. Kushi, J. Teas, Y. T. Gao, W. Zheng

Research output: Contribution to journalArticle

180 Citations (Scopus)

Abstract

We evaluated the association of soyfood intake and breast cancer risk in a population-based case-control study among Chinese women in Shanghai. Included in the study were 1459 cases and 1556 age-matched controls, with respective response rates of 91.1% and 90.3%. Usual soyfood intake was assessed using a food frequency questionnaire (FFQ). Separate analyses were performed for all subjects and for the subset who reported no recent change in soyfood intake. The intake levels of soyfoods among women in Shanghai are high, with 96.6% women reporting soyfood consumption at least once a week. A statistically non-significant reduced risk (odds ratio (OR) = 0.78 95% Cl = 0.52-1.16) of breast cancer was observed among those who reported eating soyfood at least once a week. Compared to those in the lowest decile intake group, women in the highest decile intake group had a 30% reduced risk of breast cancer (OR = 0.66, 95% Cl = 0.46-0.95), but no monotonic dose-response relation was observed (P for trend, 0.28). Stratified analyses showed that the inverse association was restricted primarily among women who had a high body mass index (BMI), with an adjusted OR of 0.30 (95% Cl = 0.10-0.94) observed for the highest intake group. The reduction in risk was stronger for breast cancer positive for both oestrogen receptor (ER) and progesterone receptor (PR) (OR = 0.44, 95% Cl = 0.25-0.78) than those with other ER/PR status. More pronounced inverse associations were observed in analyses among those who reported no recent change in soyfood intake than those conducted in all subjects. A dose-response relation between soyfood intake and breast cancer risk was observed in this subset of women (Pfor trend, 0.02), with an OR of 0.46 (95%Cl = 0.28-0.75) for those in the highest decile intake group. No clear monotonic dose-response relation was found between soyfood intake and breast cancer risk among regular soy eaters, but nevertheless the results suggest that regular soyfood consumption may reduce the risk of breast cancer, particularly for those positive for ER and PR; the effect may be modified by body mass index.

Original languageEnglish (US)
Pages (from-to)372-378
Number of pages7
JournalBritish Journal of Cancer
Volume85
Issue number3
DOIs
StatePublished - Aug 3 2001
Externally publishedYes

Fingerprint

Case-Control Studies
Breast Neoplasms
Odds Ratio
Population
Progesterone Receptors
Body Mass Index
Risk Reduction Behavior
Estrogen Receptors
Eating
Food

Keywords

  • Body mass index
  • Breast cancer
  • ER and PR
  • Soyfood

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Dai, Q., Shu, X. O., Jin, F., Potter, J. D., Kushi, L. H., Teas, J., ... Zheng, W. (2001). Population-based case-control study of soyfood intake and breast cancer risk in Shanghai. British Journal of Cancer, 85(3), 372-378. https://doi.org/10.1054/bjoc.2001.1873

Population-based case-control study of soyfood intake and breast cancer risk in Shanghai. / Dai, Q.; Shu, X. O.; Jin, F.; Potter, J. D.; Kushi, L. H.; Teas, J.; Gao, Y. T.; Zheng, W.

In: British Journal of Cancer, Vol. 85, No. 3, 03.08.2001, p. 372-378.

Research output: Contribution to journalArticle

Dai, Q, Shu, XO, Jin, F, Potter, JD, Kushi, LH, Teas, J, Gao, YT & Zheng, W 2001, 'Population-based case-control study of soyfood intake and breast cancer risk in Shanghai', British Journal of Cancer, vol. 85, no. 3, pp. 372-378. https://doi.org/10.1054/bjoc.2001.1873
Dai, Q. ; Shu, X. O. ; Jin, F. ; Potter, J. D. ; Kushi, L. H. ; Teas, J. ; Gao, Y. T. ; Zheng, W. / Population-based case-control study of soyfood intake and breast cancer risk in Shanghai. In: British Journal of Cancer. 2001 ; Vol. 85, No. 3. pp. 372-378.
@article{f95feab7316641109f5d7120cbd544ae,
title = "Population-based case-control study of soyfood intake and breast cancer risk in Shanghai",
abstract = "We evaluated the association of soyfood intake and breast cancer risk in a population-based case-control study among Chinese women in Shanghai. Included in the study were 1459 cases and 1556 age-matched controls, with respective response rates of 91.1{\%} and 90.3{\%}. Usual soyfood intake was assessed using a food frequency questionnaire (FFQ). Separate analyses were performed for all subjects and for the subset who reported no recent change in soyfood intake. The intake levels of soyfoods among women in Shanghai are high, with 96.6{\%} women reporting soyfood consumption at least once a week. A statistically non-significant reduced risk (odds ratio (OR) = 0.78 95{\%} Cl = 0.52-1.16) of breast cancer was observed among those who reported eating soyfood at least once a week. Compared to those in the lowest decile intake group, women in the highest decile intake group had a 30{\%} reduced risk of breast cancer (OR = 0.66, 95{\%} Cl = 0.46-0.95), but no monotonic dose-response relation was observed (P for trend, 0.28). Stratified analyses showed that the inverse association was restricted primarily among women who had a high body mass index (BMI), with an adjusted OR of 0.30 (95{\%} Cl = 0.10-0.94) observed for the highest intake group. The reduction in risk was stronger for breast cancer positive for both oestrogen receptor (ER) and progesterone receptor (PR) (OR = 0.44, 95{\%} Cl = 0.25-0.78) than those with other ER/PR status. More pronounced inverse associations were observed in analyses among those who reported no recent change in soyfood intake than those conducted in all subjects. A dose-response relation between soyfood intake and breast cancer risk was observed in this subset of women (Pfor trend, 0.02), with an OR of 0.46 (95{\%}Cl = 0.28-0.75) for those in the highest decile intake group. No clear monotonic dose-response relation was found between soyfood intake and breast cancer risk among regular soy eaters, but nevertheless the results suggest that regular soyfood consumption may reduce the risk of breast cancer, particularly for those positive for ER and PR; the effect may be modified by body mass index.",
keywords = "Body mass index, Breast cancer, ER and PR, Soyfood",
author = "Q. Dai and Shu, {X. O.} and F. Jin and Potter, {J. D.} and Kushi, {L. H.} and J. Teas and Gao, {Y. T.} and W. Zheng",
year = "2001",
month = "8",
day = "3",
doi = "10.1054/bjoc.2001.1873",
language = "English (US)",
volume = "85",
pages = "372--378",
journal = "British Journal of Cancer",
issn = "0007-0920",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - Population-based case-control study of soyfood intake and breast cancer risk in Shanghai

AU - Dai, Q.

AU - Shu, X. O.

AU - Jin, F.

AU - Potter, J. D.

AU - Kushi, L. H.

AU - Teas, J.

AU - Gao, Y. T.

AU - Zheng, W.

PY - 2001/8/3

Y1 - 2001/8/3

N2 - We evaluated the association of soyfood intake and breast cancer risk in a population-based case-control study among Chinese women in Shanghai. Included in the study were 1459 cases and 1556 age-matched controls, with respective response rates of 91.1% and 90.3%. Usual soyfood intake was assessed using a food frequency questionnaire (FFQ). Separate analyses were performed for all subjects and for the subset who reported no recent change in soyfood intake. The intake levels of soyfoods among women in Shanghai are high, with 96.6% women reporting soyfood consumption at least once a week. A statistically non-significant reduced risk (odds ratio (OR) = 0.78 95% Cl = 0.52-1.16) of breast cancer was observed among those who reported eating soyfood at least once a week. Compared to those in the lowest decile intake group, women in the highest decile intake group had a 30% reduced risk of breast cancer (OR = 0.66, 95% Cl = 0.46-0.95), but no monotonic dose-response relation was observed (P for trend, 0.28). Stratified analyses showed that the inverse association was restricted primarily among women who had a high body mass index (BMI), with an adjusted OR of 0.30 (95% Cl = 0.10-0.94) observed for the highest intake group. The reduction in risk was stronger for breast cancer positive for both oestrogen receptor (ER) and progesterone receptor (PR) (OR = 0.44, 95% Cl = 0.25-0.78) than those with other ER/PR status. More pronounced inverse associations were observed in analyses among those who reported no recent change in soyfood intake than those conducted in all subjects. A dose-response relation between soyfood intake and breast cancer risk was observed in this subset of women (Pfor trend, 0.02), with an OR of 0.46 (95%Cl = 0.28-0.75) for those in the highest decile intake group. No clear monotonic dose-response relation was found between soyfood intake and breast cancer risk among regular soy eaters, but nevertheless the results suggest that regular soyfood consumption may reduce the risk of breast cancer, particularly for those positive for ER and PR; the effect may be modified by body mass index.

AB - We evaluated the association of soyfood intake and breast cancer risk in a population-based case-control study among Chinese women in Shanghai. Included in the study were 1459 cases and 1556 age-matched controls, with respective response rates of 91.1% and 90.3%. Usual soyfood intake was assessed using a food frequency questionnaire (FFQ). Separate analyses were performed for all subjects and for the subset who reported no recent change in soyfood intake. The intake levels of soyfoods among women in Shanghai are high, with 96.6% women reporting soyfood consumption at least once a week. A statistically non-significant reduced risk (odds ratio (OR) = 0.78 95% Cl = 0.52-1.16) of breast cancer was observed among those who reported eating soyfood at least once a week. Compared to those in the lowest decile intake group, women in the highest decile intake group had a 30% reduced risk of breast cancer (OR = 0.66, 95% Cl = 0.46-0.95), but no monotonic dose-response relation was observed (P for trend, 0.28). Stratified analyses showed that the inverse association was restricted primarily among women who had a high body mass index (BMI), with an adjusted OR of 0.30 (95% Cl = 0.10-0.94) observed for the highest intake group. The reduction in risk was stronger for breast cancer positive for both oestrogen receptor (ER) and progesterone receptor (PR) (OR = 0.44, 95% Cl = 0.25-0.78) than those with other ER/PR status. More pronounced inverse associations were observed in analyses among those who reported no recent change in soyfood intake than those conducted in all subjects. A dose-response relation between soyfood intake and breast cancer risk was observed in this subset of women (Pfor trend, 0.02), with an OR of 0.46 (95%Cl = 0.28-0.75) for those in the highest decile intake group. No clear monotonic dose-response relation was found between soyfood intake and breast cancer risk among regular soy eaters, but nevertheless the results suggest that regular soyfood consumption may reduce the risk of breast cancer, particularly for those positive for ER and PR; the effect may be modified by body mass index.

KW - Body mass index

KW - Breast cancer

KW - ER and PR

KW - Soyfood

UR - http://www.scopus.com/inward/record.url?scp=0035800440&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035800440&partnerID=8YFLogxK

U2 - 10.1054/bjoc.2001.1873

DO - 10.1054/bjoc.2001.1873

M3 - Article

C2 - 11487268

AN - SCOPUS:0035800440

VL - 85

SP - 372

EP - 378

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 3

ER -