Population based analysis of survival in patients with renal cell carcinoma and venous tumor thrombus

Jared M Whitson, Adam C. Reese, Maxwell V. Meng

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objectives: To identify prognostic factors for renal cell carcinoma (RCC) with venous tumor thrombus (VTT) and determine the significance of thrombus level on survival. Materials and methods: Patients within the Surveillance, Epidemiology, and End Results (SEER) database with RCC and VTT were identified and included if managed surgically. The Kaplan-Meier method and Cox regression analyses were performed to identify factors associated with disease-specific survival. Results: A total of 1,875 patients met the inclusion criteria. One-year survival for patients undergoing surgery was 60% for patients with metastases and 90% for those without. Factors associated with worse survival included larger tumor size (HR 1.2, 95% CI 1.0-1.4), medullary, collecting duct, or sarcomatoid histology (HR 2.2, 95% CI 1.5-3.3), Fuhrman grade 3 (HR 2.2, 95% CI 1.5-3.3) or grade 4 (HR 2.9, 95% CI 1.8-4.5) tumors, positive lymph nodes (HR 1.5, 95% CI 1.0-2.0), and metastases (HR 3.5, 95% CI 2.6-4.8). Thrombus level above the diaphragm (T3c) was not significantly associated with worse survival (HR 1.4, 95% CI 0.8-2.5). Conclusions: In this large, population-based study of patients with RCC and VTT, we identify several disease-specific factors strongly associated with cancer-specific mortality. After controlling for adverse prognostic factors, thrombus level was not associated with worse outcome.

Original languageEnglish (US)
Pages (from-to)259-263
Number of pages5
JournalUrologic Oncology: Seminars and Original Investigations
Volume31
Issue number2
DOIs
StatePublished - Feb 2013
Externally publishedYes

Fingerprint

Survival Analysis
Renal Cell Carcinoma
Thrombosis
Survival
Population
Neoplasms
Neoplasm Metastasis
Diaphragm
Histology
Epidemiology
Lymph Nodes
Regression Analysis
Databases
Mortality

Keywords

  • Carcinoma
  • Inferior
  • Nephrectomy
  • Renal cell
  • Survival
  • Vena cava

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

Population based analysis of survival in patients with renal cell carcinoma and venous tumor thrombus. / Whitson, Jared M; Reese, Adam C.; Meng, Maxwell V.

In: Urologic Oncology: Seminars and Original Investigations, Vol. 31, No. 2, 02.2013, p. 259-263.

Research output: Contribution to journalArticle

@article{dc3113bb1dab4fde8e3f49dfd51b107f,
title = "Population based analysis of survival in patients with renal cell carcinoma and venous tumor thrombus",
abstract = "Objectives: To identify prognostic factors for renal cell carcinoma (RCC) with venous tumor thrombus (VTT) and determine the significance of thrombus level on survival. Materials and methods: Patients within the Surveillance, Epidemiology, and End Results (SEER) database with RCC and VTT were identified and included if managed surgically. The Kaplan-Meier method and Cox regression analyses were performed to identify factors associated with disease-specific survival. Results: A total of 1,875 patients met the inclusion criteria. One-year survival for patients undergoing surgery was 60{\%} for patients with metastases and 90{\%} for those without. Factors associated with worse survival included larger tumor size (HR 1.2, 95{\%} CI 1.0-1.4), medullary, collecting duct, or sarcomatoid histology (HR 2.2, 95{\%} CI 1.5-3.3), Fuhrman grade 3 (HR 2.2, 95{\%} CI 1.5-3.3) or grade 4 (HR 2.9, 95{\%} CI 1.8-4.5) tumors, positive lymph nodes (HR 1.5, 95{\%} CI 1.0-2.0), and metastases (HR 3.5, 95{\%} CI 2.6-4.8). Thrombus level above the diaphragm (T3c) was not significantly associated with worse survival (HR 1.4, 95{\%} CI 0.8-2.5). Conclusions: In this large, population-based study of patients with RCC and VTT, we identify several disease-specific factors strongly associated with cancer-specific mortality. After controlling for adverse prognostic factors, thrombus level was not associated with worse outcome.",
keywords = "Carcinoma, Inferior, Nephrectomy, Renal cell, Survival, Vena cava",
author = "Whitson, {Jared M} and Reese, {Adam C.} and Meng, {Maxwell V.}",
year = "2013",
month = "2",
doi = "10.1016/j.urolonc.2010.11.017",
language = "English (US)",
volume = "31",
pages = "259--263",
journal = "Urologic Oncology",
issn = "1078-1439",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Population based analysis of survival in patients with renal cell carcinoma and venous tumor thrombus

AU - Whitson, Jared M

AU - Reese, Adam C.

AU - Meng, Maxwell V.

PY - 2013/2

Y1 - 2013/2

N2 - Objectives: To identify prognostic factors for renal cell carcinoma (RCC) with venous tumor thrombus (VTT) and determine the significance of thrombus level on survival. Materials and methods: Patients within the Surveillance, Epidemiology, and End Results (SEER) database with RCC and VTT were identified and included if managed surgically. The Kaplan-Meier method and Cox regression analyses were performed to identify factors associated with disease-specific survival. Results: A total of 1,875 patients met the inclusion criteria. One-year survival for patients undergoing surgery was 60% for patients with metastases and 90% for those without. Factors associated with worse survival included larger tumor size (HR 1.2, 95% CI 1.0-1.4), medullary, collecting duct, or sarcomatoid histology (HR 2.2, 95% CI 1.5-3.3), Fuhrman grade 3 (HR 2.2, 95% CI 1.5-3.3) or grade 4 (HR 2.9, 95% CI 1.8-4.5) tumors, positive lymph nodes (HR 1.5, 95% CI 1.0-2.0), and metastases (HR 3.5, 95% CI 2.6-4.8). Thrombus level above the diaphragm (T3c) was not significantly associated with worse survival (HR 1.4, 95% CI 0.8-2.5). Conclusions: In this large, population-based study of patients with RCC and VTT, we identify several disease-specific factors strongly associated with cancer-specific mortality. After controlling for adverse prognostic factors, thrombus level was not associated with worse outcome.

AB - Objectives: To identify prognostic factors for renal cell carcinoma (RCC) with venous tumor thrombus (VTT) and determine the significance of thrombus level on survival. Materials and methods: Patients within the Surveillance, Epidemiology, and End Results (SEER) database with RCC and VTT were identified and included if managed surgically. The Kaplan-Meier method and Cox regression analyses were performed to identify factors associated with disease-specific survival. Results: A total of 1,875 patients met the inclusion criteria. One-year survival for patients undergoing surgery was 60% for patients with metastases and 90% for those without. Factors associated with worse survival included larger tumor size (HR 1.2, 95% CI 1.0-1.4), medullary, collecting duct, or sarcomatoid histology (HR 2.2, 95% CI 1.5-3.3), Fuhrman grade 3 (HR 2.2, 95% CI 1.5-3.3) or grade 4 (HR 2.9, 95% CI 1.8-4.5) tumors, positive lymph nodes (HR 1.5, 95% CI 1.0-2.0), and metastases (HR 3.5, 95% CI 2.6-4.8). Thrombus level above the diaphragm (T3c) was not significantly associated with worse survival (HR 1.4, 95% CI 0.8-2.5). Conclusions: In this large, population-based study of patients with RCC and VTT, we identify several disease-specific factors strongly associated with cancer-specific mortality. After controlling for adverse prognostic factors, thrombus level was not associated with worse outcome.

KW - Carcinoma

KW - Inferior

KW - Nephrectomy

KW - Renal cell

KW - Survival

KW - Vena cava

UR - http://www.scopus.com/inward/record.url?scp=84875235440&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875235440&partnerID=8YFLogxK

U2 - 10.1016/j.urolonc.2010.11.017

DO - 10.1016/j.urolonc.2010.11.017

M3 - Article

C2 - 21795070

AN - SCOPUS:84875235440

VL - 31

SP - 259

EP - 263

JO - Urologic Oncology

JF - Urologic Oncology

SN - 1078-1439

IS - 2

ER -