Polyurethane shape-memory polymers demonstrate functional biocompatibility in vitro

Maricel Cabanlit, Duncan Maitland, Thomas Wilson, Scott Simon, Theodore Wun, M. Eric Gershwin, Judith A Van de Water

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Shape memory polymers (SMPs) are a class of polymeric materials used in various medical interventions such as vascular stents. In this work, two SMPs, thermoplastic (TP) and thermoset (TS), have been measured in vitro for the degree of cellular and protein adhesion, their ability to stimulate inflammatory cytokine production, as well as the effects of the SMPs on the haemostatic system. The stimulatory properties of SMPs on neutrophils have also been directly addressed. Based on the studies of SMP biocompatibility as defined by inflammation, thrombogenesis, and the activation of both platelets and neutrophils, the TS and TP SMP materials are unlikely to stimulate an inflammatory response in vivo. (Graph Presented)

Original languageEnglish (US)
Pages (from-to)48-55
Number of pages8
JournalMacromolecular Bioscience
Volume7
Issue number1
DOIs
StatePublished - Jan 5 2007

Keywords

  • Biocompatibility
  • Cytokine
  • Inflammation
  • Polyurethanes
  • Shape memory polymer

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry
  • Bioengineering

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