Polyurethane shape-memory polymers demonstrate functional biocompatibility in vitro

Maricel Cabanlit; Duncan Maitland; Thomas Wilson; Scott Simon; Theodore Wun; M. Eric Gershwin; Judith A Van de Water

doi:10.1002/mabi.200600177

Polyurethane shape-memory polymers demonstrate functional biocompatibility in vitro

Maricel Cabanlit, Duncan Maitland, Thomas Wilson, Scott Simon, Theodore Wun, M. Eric Gershwin, Judith A Van de Water

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Shape memory polymers (SMPs) are a class of polymeric materials used in various medical interventions such as vascular stents. In this work, two SMPs, thermoplastic (TP) and thermoset (TS), have been measured in vitro for the degree of cellular and protein adhesion, their ability to stimulate inflammatory cytokine production, as well as the effects of the SMPs on the haemostatic system. The stimulatory properties of SMPs on neutrophils have also been directly addressed. Based on the studies of SMP biocompatibility as defined by inflammation, thrombogenesis, and the activation of both platelets and neutrophils, the TS and TP SMP materials are unlikely to stimulate an inflammatory response in vivo. (Graph Presented)

Original language	English (US)
Pages (from-to)	48-55
Number of pages	8
Journal	Macromolecular Bioscience
Volume	7
Issue number	1
DOIs	https://doi.org/10.1002/mabi.200600177
State	Published - Jan 5 2007

Keywords

Biocompatibility
Cytokine
Inflammation
Polyurethanes
Shape memory polymer

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Biochemistry
Biomaterials
Polymers and Plastics
Materials Chemistry
Bioengineering

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abstract = "Shape memory polymers (SMPs) are a class of polymeric materials used in various medical interventions such as vascular stents. In this work, two SMPs, thermoplastic (TP) and thermoset (TS), have been measured in vitro for the degree of cellular and protein adhesion, their ability to stimulate inflammatory cytokine production, as well as the effects of the SMPs on the haemostatic system. The stimulatory properties of SMPs on neutrophils have also been directly addressed. Based on the studies of SMP biocompatibility as defined by inflammation, thrombogenesis, and the activation of both platelets and neutrophils, the TS and TP SMP materials are unlikely to stimulate an inflammatory response in vivo. (Graph Presented)",

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AU - Maitland, Duncan

AU - Wilson, Thomas

AU - Simon, Scott

AU - Wun, Theodore

AU - Gershwin, M. Eric

AU - Van de Water, Judith A

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AB - Shape memory polymers (SMPs) are a class of polymeric materials used in various medical interventions such as vascular stents. In this work, two SMPs, thermoplastic (TP) and thermoset (TS), have been measured in vitro for the degree of cellular and protein adhesion, their ability to stimulate inflammatory cytokine production, as well as the effects of the SMPs on the haemostatic system. The stimulatory properties of SMPs on neutrophils have also been directly addressed. Based on the studies of SMP biocompatibility as defined by inflammation, thrombogenesis, and the activation of both platelets and neutrophils, the TS and TP SMP materials are unlikely to stimulate an inflammatory response in vivo. (Graph Presented)

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