Abstract
Shape memory polymers (SMPs) are a class of polymeric materials used in various medical interventions such as vascular stents. In this work, two SMPs, thermoplastic (TP) and thermoset (TS), have been measured in vitro for the degree of cellular and protein adhesion, their ability to stimulate inflammatory cytokine production, as well as the effects of the SMPs on the haemostatic system. The stimulatory properties of SMPs on neutrophils have also been directly addressed. Based on the studies of SMP biocompatibility as defined by inflammation, thrombogenesis, and the activation of both platelets and neutrophils, the TS and TP SMP materials are unlikely to stimulate an inflammatory response in vivo. (Graph Presented)
| Original language | English (US) |
|---|---|
| Pages (from-to) | 48-55 |
| Number of pages | 8 |
| Journal | Macromolecular Bioscience |
| Volume | 7 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 5 2007 |
Fingerprint
Keywords
- Biocompatibility
- Cytokine
- Inflammation
- Polyurethanes
- Shape memory polymer
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Biomaterials
- Polymers and Plastics
- Materials Chemistry
- Bioengineering
Cite this
Polyurethane shape-memory polymers demonstrate functional biocompatibility in vitro. / Cabanlit, Maricel; Maitland, Duncan; Wilson, Thomas; Simon, Scott; Wun, Theodore; Gershwin, M. Eric; Van de Water, Judith A.
In: Macromolecular Bioscience, Vol. 7, No. 1, 05.01.2007, p. 48-55.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Polyurethane shape-memory polymers demonstrate functional biocompatibility in vitro
AU - Cabanlit, Maricel
AU - Maitland, Duncan
AU - Wilson, Thomas
AU - Simon, Scott
AU - Wun, Theodore
AU - Gershwin, M. Eric
AU - Van de Water, Judith A
PY - 2007/1/5
Y1 - 2007/1/5
N2 - Shape memory polymers (SMPs) are a class of polymeric materials used in various medical interventions such as vascular stents. In this work, two SMPs, thermoplastic (TP) and thermoset (TS), have been measured in vitro for the degree of cellular and protein adhesion, their ability to stimulate inflammatory cytokine production, as well as the effects of the SMPs on the haemostatic system. The stimulatory properties of SMPs on neutrophils have also been directly addressed. Based on the studies of SMP biocompatibility as defined by inflammation, thrombogenesis, and the activation of both platelets and neutrophils, the TS and TP SMP materials are unlikely to stimulate an inflammatory response in vivo. (Graph Presented)
AB - Shape memory polymers (SMPs) are a class of polymeric materials used in various medical interventions such as vascular stents. In this work, two SMPs, thermoplastic (TP) and thermoset (TS), have been measured in vitro for the degree of cellular and protein adhesion, their ability to stimulate inflammatory cytokine production, as well as the effects of the SMPs on the haemostatic system. The stimulatory properties of SMPs on neutrophils have also been directly addressed. Based on the studies of SMP biocompatibility as defined by inflammation, thrombogenesis, and the activation of both platelets and neutrophils, the TS and TP SMP materials are unlikely to stimulate an inflammatory response in vivo. (Graph Presented)
KW - Biocompatibility
KW - Cytokine
KW - Inflammation
KW - Polyurethanes
KW - Shape memory polymer
UR - http://www.scopus.com/inward/record.url?scp=33846702374&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846702374&partnerID=8YFLogxK
U2 - 10.1002/mabi.200600177
DO - 10.1002/mabi.200600177
M3 - Article
C2 - 17238230
AN - SCOPUS:33846702374
VL - 7
SP - 48
EP - 55
JO - Macromolecular Bioscience
JF - Macromolecular Bioscience
SN - 1616-5187
IS - 1
ER -