Abstract
Shape memory polymers (SMPs) are a class of polymeric materials used in various medical interventions such as vascular stents. In this work, two SMPs, thermoplastic (TP) and thermoset (TS), have been measured in vitro for the degree of cellular and protein adhesion, their ability to stimulate inflammatory cytokine production, as well as the effects of the SMPs on the haemostatic system. The stimulatory properties of SMPs on neutrophils have also been directly addressed. Based on the studies of SMP biocompatibility as defined by inflammation, thrombogenesis, and the activation of both platelets and neutrophils, the TS and TP SMP materials are unlikely to stimulate an inflammatory response in vivo. (Graph Presented)
| Original language | English (US) |
|---|---|
| Pages (from-to) | 48-55 |
| Number of pages | 8 |
| Journal | Macromolecular Bioscience |
| Volume | 7 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 5 2007 |
Keywords
- Biocompatibility
- Cytokine
- Inflammation
- Polyurethanes
- Shape memory polymer
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Biomaterials
- Polymers and Plastics
- Materials Chemistry
- Bioengineering
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Cite this
Cabanlit, M., Maitland, D., Wilson, T., Simon, S., Wun, T., Gershwin, M. E., & Van de Water, J. A. (2007). Polyurethane shape-memory polymers demonstrate functional biocompatibility in vitro. Macromolecular Bioscience, 7(1), 48-55. https://doi.org/10.1002/mabi.200600177