Polyunsaturated fatty acids, DNA repair single nucleotide polymorphisms and colorectal cancer in the Singapore Chinese Health Study

Mariana C. Stern, Lesley M. Butler, Román Corral, Amit D. Joshi, Jian Min Yuan, Woon Puay Koh, Mimi C. Yu

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Animal and in vitrostudies support a role for polyunsaturated fatty acids (PUFAs) in colon carcinogenesis; however, the epidemiological evidence is inconclusive. Recently, we investigated their role within the Singapore Chinese Health Study, a population-based cohort of Singapore Chinese men and women. We reported that a high intake of marine n-3 PUFAs was associated with an increased risk of colorectal cancer (CRC). Oxidation of PUFAs incorporated into cell membranes generates lipid hydroperoxides, which can be mutagenic. In this report, we investigated whether single nucleotide polymorphisms (SNPs) in DNA repair genes modified the effect of PUFAs on CRC risk using a nested case-control study within the Singapore Chinese Health Study. We genotyped 1,181 controls and 311 cases (180 colon and 131 rectal cancer) for SNPs in the XRCC1 (Arg194Trp, Arg399Gln), OGG1 (Ser326Cys), PARP (Val762Ala, Lys940Arg), and XPD (Asp312Asn, Lys751Gln) genes. We observed that the PARP Val762Ala SNP modified the association between marine n-3 PUFA and rectal cancer risk, with no evidence of interaction among colon cancer (heterogeneity test p = 0.003). Our results suggest a positive association between high intake of marine n-3 PUFA and rectal cancer risk among carriers of at least one PARP codon 762 Ala allele (odds ratio = 1.7, 95% confidence interval = 1.1-2.7).

Original languageEnglish (US)
Pages (from-to)273-279
Number of pages7
JournalJournal of Nutrigenetics and Nutrigenomics
Volume2
Issue number6
DOIs
StatePublished - Aug 2010
Externally publishedYes

Keywords

  • Colorectal cancer
  • N-3 Polyunsaturated fatty acids
  • PARP
  • Polyunsaturated fatty acids
  • Singapore

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Genetics
  • Food Science

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