Polyunsaturated fatty acids, DNA repair single nucleotide polymorphisms and colorectal cancer in the Singapore Chinese Health Study

Mariana C. Stern, Lesley M. Butler, Román Corral, Amit D. Joshi, Jian Min Yuan, Woon Puay Koh, Mimi C. Yu

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Animal and in vitrostudies support a role for polyunsaturated fatty acids (PUFAs) in colon carcinogenesis; however, the epidemiological evidence is inconclusive. Recently, we investigated their role within the Singapore Chinese Health Study, a population-based cohort of Singapore Chinese men and women. We reported that a high intake of marine n-3 PUFAs was associated with an increased risk of colorectal cancer (CRC). Oxidation of PUFAs incorporated into cell membranes generates lipid hydroperoxides, which can be mutagenic. In this report, we investigated whether single nucleotide polymorphisms (SNPs) in DNA repair genes modified the effect of PUFAs on CRC risk using a nested case-control study within the Singapore Chinese Health Study. We genotyped 1,181 controls and 311 cases (180 colon and 131 rectal cancer) for SNPs in the XRCC1 (Arg194Trp, Arg399Gln), OGG1 (Ser326Cys), PARP (Val762Ala, Lys940Arg), and XPD (Asp312Asn, Lys751Gln) genes. We observed that the PARP Val762Ala SNP modified the association between marine n-3 PUFA and rectal cancer risk, with no evidence of interaction among colon cancer (heterogeneity test p = 0.003). Our results suggest a positive association between high intake of marine n-3 PUFA and rectal cancer risk among carriers of at least one PARP codon 762 Ala allele (odds ratio = 1.7, 95% confidence interval = 1.1-2.7).

Original languageEnglish (US)
Pages (from-to)273-279
Number of pages7
JournalJournal of Nutrigenetics and Nutrigenomics
Volume2
Issue number6
DOIs
StatePublished - Aug 2010
Externally publishedYes

Fingerprint

Singapore
DNA repair
colorectal neoplasms
Unsaturated Fatty Acids
DNA Repair
single nucleotide polymorphism
Single Nucleotide Polymorphism
polyunsaturated fatty acids
Colorectal Neoplasms
Omega-3 Fatty Acids
Rectal Neoplasms
Health
omega-3 fatty acids
Colon
colon
Lipid Peroxides
Membrane Lipids
Codon
Colonic Neoplasms
Genes

Keywords

  • Colorectal cancer
  • N-3 Polyunsaturated fatty acids
  • PARP
  • Polyunsaturated fatty acids
  • Singapore

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Genetics
  • Food Science

Cite this

Polyunsaturated fatty acids, DNA repair single nucleotide polymorphisms and colorectal cancer in the Singapore Chinese Health Study. / Stern, Mariana C.; Butler, Lesley M.; Corral, Román; Joshi, Amit D.; Yuan, Jian Min; Koh, Woon Puay; Yu, Mimi C.

In: Journal of Nutrigenetics and Nutrigenomics, Vol. 2, No. 6, 08.2010, p. 273-279.

Research output: Contribution to journalArticle

Stern, Mariana C. ; Butler, Lesley M. ; Corral, Román ; Joshi, Amit D. ; Yuan, Jian Min ; Koh, Woon Puay ; Yu, Mimi C. / Polyunsaturated fatty acids, DNA repair single nucleotide polymorphisms and colorectal cancer in the Singapore Chinese Health Study. In: Journal of Nutrigenetics and Nutrigenomics. 2010 ; Vol. 2, No. 6. pp. 273-279.
@article{b6cebd6585db41a4bc5d46db272f9d7d,
title = "Polyunsaturated fatty acids, DNA repair single nucleotide polymorphisms and colorectal cancer in the Singapore Chinese Health Study",
abstract = "Animal and in vitrostudies support a role for polyunsaturated fatty acids (PUFAs) in colon carcinogenesis; however, the epidemiological evidence is inconclusive. Recently, we investigated their role within the Singapore Chinese Health Study, a population-based cohort of Singapore Chinese men and women. We reported that a high intake of marine n-3 PUFAs was associated with an increased risk of colorectal cancer (CRC). Oxidation of PUFAs incorporated into cell membranes generates lipid hydroperoxides, which can be mutagenic. In this report, we investigated whether single nucleotide polymorphisms (SNPs) in DNA repair genes modified the effect of PUFAs on CRC risk using a nested case-control study within the Singapore Chinese Health Study. We genotyped 1,181 controls and 311 cases (180 colon and 131 rectal cancer) for SNPs in the XRCC1 (Arg194Trp, Arg399Gln), OGG1 (Ser326Cys), PARP (Val762Ala, Lys940Arg), and XPD (Asp312Asn, Lys751Gln) genes. We observed that the PARP Val762Ala SNP modified the association between marine n-3 PUFA and rectal cancer risk, with no evidence of interaction among colon cancer (heterogeneity test p = 0.003). Our results suggest a positive association between high intake of marine n-3 PUFA and rectal cancer risk among carriers of at least one PARP codon 762 Ala allele (odds ratio = 1.7, 95{\%} confidence interval = 1.1-2.7).",
keywords = "Colorectal cancer, N-3 Polyunsaturated fatty acids, PARP, Polyunsaturated fatty acids, Singapore",
author = "Stern, {Mariana C.} and Butler, {Lesley M.} and Rom{\'a}n Corral and Joshi, {Amit D.} and Yuan, {Jian Min} and Koh, {Woon Puay} and Yu, {Mimi C.}",
year = "2010",
month = "8",
doi = "10.1159/000308467",
language = "English (US)",
volume = "2",
pages = "273--279",
journal = "Lifestyle Genomics",
issn = "2504-3161",
publisher = "S. Karger AG",
number = "6",

}

TY - JOUR

T1 - Polyunsaturated fatty acids, DNA repair single nucleotide polymorphisms and colorectal cancer in the Singapore Chinese Health Study

AU - Stern, Mariana C.

AU - Butler, Lesley M.

AU - Corral, Román

AU - Joshi, Amit D.

AU - Yuan, Jian Min

AU - Koh, Woon Puay

AU - Yu, Mimi C.

PY - 2010/8

Y1 - 2010/8

N2 - Animal and in vitrostudies support a role for polyunsaturated fatty acids (PUFAs) in colon carcinogenesis; however, the epidemiological evidence is inconclusive. Recently, we investigated their role within the Singapore Chinese Health Study, a population-based cohort of Singapore Chinese men and women. We reported that a high intake of marine n-3 PUFAs was associated with an increased risk of colorectal cancer (CRC). Oxidation of PUFAs incorporated into cell membranes generates lipid hydroperoxides, which can be mutagenic. In this report, we investigated whether single nucleotide polymorphisms (SNPs) in DNA repair genes modified the effect of PUFAs on CRC risk using a nested case-control study within the Singapore Chinese Health Study. We genotyped 1,181 controls and 311 cases (180 colon and 131 rectal cancer) for SNPs in the XRCC1 (Arg194Trp, Arg399Gln), OGG1 (Ser326Cys), PARP (Val762Ala, Lys940Arg), and XPD (Asp312Asn, Lys751Gln) genes. We observed that the PARP Val762Ala SNP modified the association between marine n-3 PUFA and rectal cancer risk, with no evidence of interaction among colon cancer (heterogeneity test p = 0.003). Our results suggest a positive association between high intake of marine n-3 PUFA and rectal cancer risk among carriers of at least one PARP codon 762 Ala allele (odds ratio = 1.7, 95% confidence interval = 1.1-2.7).

AB - Animal and in vitrostudies support a role for polyunsaturated fatty acids (PUFAs) in colon carcinogenesis; however, the epidemiological evidence is inconclusive. Recently, we investigated their role within the Singapore Chinese Health Study, a population-based cohort of Singapore Chinese men and women. We reported that a high intake of marine n-3 PUFAs was associated with an increased risk of colorectal cancer (CRC). Oxidation of PUFAs incorporated into cell membranes generates lipid hydroperoxides, which can be mutagenic. In this report, we investigated whether single nucleotide polymorphisms (SNPs) in DNA repair genes modified the effect of PUFAs on CRC risk using a nested case-control study within the Singapore Chinese Health Study. We genotyped 1,181 controls and 311 cases (180 colon and 131 rectal cancer) for SNPs in the XRCC1 (Arg194Trp, Arg399Gln), OGG1 (Ser326Cys), PARP (Val762Ala, Lys940Arg), and XPD (Asp312Asn, Lys751Gln) genes. We observed that the PARP Val762Ala SNP modified the association between marine n-3 PUFA and rectal cancer risk, with no evidence of interaction among colon cancer (heterogeneity test p = 0.003). Our results suggest a positive association between high intake of marine n-3 PUFA and rectal cancer risk among carriers of at least one PARP codon 762 Ala allele (odds ratio = 1.7, 95% confidence interval = 1.1-2.7).

KW - Colorectal cancer

KW - N-3 Polyunsaturated fatty acids

KW - PARP

KW - Polyunsaturated fatty acids

KW - Singapore

UR - http://www.scopus.com/inward/record.url?scp=77953553597&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953553597&partnerID=8YFLogxK

U2 - 10.1159/000308467

DO - 10.1159/000308467

M3 - Article

C2 - 20559012

AN - SCOPUS:77953553597

VL - 2

SP - 273

EP - 279

JO - Lifestyle Genomics

JF - Lifestyle Genomics

SN - 2504-3161

IS - 6

ER -