Polyunsaturated fatty acids and their effects on cardiovascular disease

Bradley P. Ander; Chantal M.C. Dupasquier; Michele A. Prociuk; Grant N. Pierce

Polyunsaturated fatty acids and their effects on cardiovascular disease

Bradley P. Ander, Chantal M.C. Dupasquier, Michele A. Prociuk, Grant N. Pierce

Research output: Contribution to journal › Review article › peer-review

Abstract

Dietary polyunsaturated fatty acids (PUFAs) affect a wide variety of physiological processes. Much attention has been given to the n-3 PUFAs and their role in the prevention and treatment of cardiovascular disease, stemming from evidence obtained through a number of epidemiological studies and clinical trials. Investigators are now focused on elucidating the pathways and mechanisms for the biological action of n-3 PUFAs. Dietary intervention is recognized as a key measure in patient therapy and in the maintenance of human health in general. This review provides a summary of several important clinical trials, and while the exact modes of action of n-3 PUFA are not known, current viewpoints regarding the mechanisms of these fatty acids on atherosclerosis, circulating lipid profile, cell membranes, cell proliferation, platelet aggregation and cardiac arrhythmias are discussed.

Original language	English (US)
Pages (from-to)	164-172
Number of pages	9
Journal	Experimental and Clinical Cardiology
Volume	8
Issue number	4
State	Published - Dec 1 2003
Externally published	Yes

Keywords

Arrhythmias
Atherosclerosis
Cardiovascular disease
Diet
Polyunsaturated fatty acids

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine
Physiology (medical)

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AU - Ander, Bradley P.

AU - Dupasquier, Chantal M.C.

AU - Prociuk, Michele A.

AU - Pierce, Grant N.

PY - 2003/12/1

Y1 - 2003/12/1

N2 - Dietary polyunsaturated fatty acids (PUFAs) affect a wide variety of physiological processes. Much attention has been given to the n-3 PUFAs and their role in the prevention and treatment of cardiovascular disease, stemming from evidence obtained through a number of epidemiological studies and clinical trials. Investigators are now focused on elucidating the pathways and mechanisms for the biological action of n-3 PUFAs. Dietary intervention is recognized as a key measure in patient therapy and in the maintenance of human health in general. This review provides a summary of several important clinical trials, and while the exact modes of action of n-3 PUFA are not known, current viewpoints regarding the mechanisms of these fatty acids on atherosclerosis, circulating lipid profile, cell membranes, cell proliferation, platelet aggregation and cardiac arrhythmias are discussed.

AB - Dietary polyunsaturated fatty acids (PUFAs) affect a wide variety of physiological processes. Much attention has been given to the n-3 PUFAs and their role in the prevention and treatment of cardiovascular disease, stemming from evidence obtained through a number of epidemiological studies and clinical trials. Investigators are now focused on elucidating the pathways and mechanisms for the biological action of n-3 PUFAs. Dietary intervention is recognized as a key measure in patient therapy and in the maintenance of human health in general. This review provides a summary of several important clinical trials, and while the exact modes of action of n-3 PUFA are not known, current viewpoints regarding the mechanisms of these fatty acids on atherosclerosis, circulating lipid profile, cell membranes, cell proliferation, platelet aggregation and cardiac arrhythmias are discussed.

KW - Arrhythmias

KW - Atherosclerosis

KW - Cardiovascular disease

KW - Diet

KW - Polyunsaturated fatty acids

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