Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions

Simon C. Dyall, Laurence Balas, Nicolas G. Bazan, J. Thomas Brenna, Nan Chiang, Felipe da Costa Souza, Jesmond Dalli, Thierry Durand, Jean Marie Galano, Pamela J. Lein, Charles N. Serhan, Ameer Y. Taha

Research output: Contribution to journalReview articlepeer-review

Abstract

Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids, and influence cellular function via effects on membrane properties, and also by acting as a precursor pool for lipid mediators. These lipid mediators are formed via activation of pathways involving at least one step of dioxygen-dependent oxidation, and are consequently called oxylipins. Their biosynthesis can be either enzymatically-dependent, utilising the promiscuous cyclooxygenase, lipoxygenase, or cytochrome P450 mixed function oxidase pathways, or nonenzymatic via free radical-catalyzed pathways. The oxylipins include the classical eicosanoids, comprising prostaglandins, thromboxanes, and leukotrienes, and also more recently identified lipid mediators. With the advent of new technologies there is growing interest in identifying these different lipid mediators and characterising their roles in health and disease. This review brings together contributions from some of those at the forefront of research into lipid mediators, who provide brief introductions and summaries of current understanding of the structure and functions of the main classes of nonclassical oxylipins. The topics covered include omega-3 and omega-6 PUFA biosynthesis pathways, focusing on the roles of the different fatty acid desaturase enzymes, oxidized linoleic acid metabolites, omega-3 PUFA-derived specialized pro-resolving mediators, elovanoids, nonenzymatically oxidized PUFAs, and fatty acid esters of hydroxy fatty acids.

Original languageEnglish (US)
Article number101165
JournalProgress in Lipid Research
Volume86
DOIs
StatePublished - Apr 2022
Externally publishedYes

Keywords

  • Elovanoids
  • FAHFA
  • Fatty acid desaturase
  • Lipid mediators
  • Maresins
  • Omega-3 PUFA
  • Oxylipins
  • Protectins
  • Resolvins
  • SPM

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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