Polyostotic lymphoma with multiple pathological fractures in a six-month-old cat

Laura K. Brockley, Kathryn L. Heading, John E. Jardine, Peter F Moore, Peter F. Bennett

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A 6-month-old female neutered domestic shorthair cat was examined for pain and swelling of the distal limbs. Swelling and malalignment of both carpi, dorsiflexion of the distal metatarsals and a mild, multicentric lymphadenopathy were detected on examination. Screening blood tests revealed a biclonal gammopathy, hypercalcemia and atypical leukocytes. Survey radiographs revealed lysis and proliferative changes within the physes. Multiple pathological physeal fractures were present, including the distal radii, metacarpal and metatarsal bones. No treatment was attempted and the patient was euthanased. Histopathology revealed infiltration by monomorphic round cells within the liver, spleen, kidney and bone marrow. Immunohistochemistry revealed strong reactivity to CD20. Clonality assays revealed clonal results for the B-cell loci, consistent with B-cell lymphoma. To the authors' knowledge this is the first report of polyostotic lymphoma with multiple pathological fractures in a cat. The predominantly distal distribution of osseous lesions is rarely reported in dogs and humans.

Original languageEnglish (US)
Pages (from-to)285-291
Number of pages7
JournalJournal of Feline Medicine and Surgery
Volume14
Issue number4
DOIs
StatePublished - 2013

Fingerprint

Spontaneous Fractures
Metatarsal Bones
lymphoma
Lymphoma
Cats
cats
Metacarpal Bones
B-lymphocytes
Hypercalcemia
Hematologic Tests
B-Cell Lymphoma
metacarpus
hypercalcemia
lymphatic diseases
carpus
Leukocytes
B-Lymphocytes
radius (bone)
Spleen
Extremities

ASJC Scopus subject areas

  • Small Animals

Cite this

Polyostotic lymphoma with multiple pathological fractures in a six-month-old cat. / Brockley, Laura K.; Heading, Kathryn L.; Jardine, John E.; Moore, Peter F; Bennett, Peter F.

In: Journal of Feline Medicine and Surgery, Vol. 14, No. 4, 2013, p. 285-291.

Research output: Contribution to journalArticle

Brockley, Laura K. ; Heading, Kathryn L. ; Jardine, John E. ; Moore, Peter F ; Bennett, Peter F. / Polyostotic lymphoma with multiple pathological fractures in a six-month-old cat. In: Journal of Feline Medicine and Surgery. 2013 ; Vol. 14, No. 4. pp. 285-291.
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