Polyomavirus infection in a free-ranging california sea lion (Zalophus californianus) with intestinal T-cell lymphoma

Kathleen M. Colegrove, James F X Wellehan, Rebecca Rivera, Peter F Moore, Frances M D Gulland, Linda J Lowenstine, Robert W. Nordhausen, Hendrik H. Nollens

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

An adult female California sea lion (Zalophus californianus) that stranded in central California was found to have a small glossal polypoid mass on gross necropsy. Histologically, the mass was consistent with a fibropapilloma, and intranuclear inclusions were found within endothelial cells lining small arterioles within the mass. Electron microscopy revealed 40-nm virions within endothelial intranuclear inclusions. Rolling circle amplification was used to obtain a partial viral genomic sequence. Sequence analysis identified the virus as a novel polyomavirus, tentatively named California sea lion polyomavirus 1. In addition, the sea lion had a severely thickened small intestine and swollen pale kidneys on gross examination. Severe renal amyloidosis with chronic interstitial nephritis was diagnosed histologically as well as T-cell intestinal lymphoma, which was confirmed via immunophenotyping and molecular clonality. The relationship, if any, between polyomavirus infection and the other disease processes in this sea lion is not known, but it is considered unlikely that the polyomavirus induced the lymphoma.

Original languageEnglish (US)
Pages (from-to)628-632
Number of pages5
JournalJournal of Veterinary Diagnostic Investigation
Volume22
Issue number4
StatePublished - Jul 1 2010

Fingerprint

Polyomavirus Infections
Sea Lions
Polyomavirus
T-Cell Lymphoma
lymphoma
T-lymphocytes
Otariidae
Intranuclear Inclusion Bodies
infection
kidneys
amyloidosis
nephritis
Kidney
Interstitial Nephritis
Immunophenotyping
tongue
virion
endothelial cells
small intestine
Arterioles

Keywords

  • California sea lion
  • Fibropapilloma
  • Molecular clonality
  • Polyomavirus

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Polyomavirus infection in a free-ranging california sea lion (Zalophus californianus) with intestinal T-cell lymphoma. / Colegrove, Kathleen M.; Wellehan, James F X; Rivera, Rebecca; Moore, Peter F; Gulland, Frances M D; Lowenstine, Linda J; Nordhausen, Robert W.; Nollens, Hendrik H.

In: Journal of Veterinary Diagnostic Investigation, Vol. 22, No. 4, 01.07.2010, p. 628-632.

Research output: Contribution to journalArticle

Colegrove, Kathleen M. ; Wellehan, James F X ; Rivera, Rebecca ; Moore, Peter F ; Gulland, Frances M D ; Lowenstine, Linda J ; Nordhausen, Robert W. ; Nollens, Hendrik H. / Polyomavirus infection in a free-ranging california sea lion (Zalophus californianus) with intestinal T-cell lymphoma. In: Journal of Veterinary Diagnostic Investigation. 2010 ; Vol. 22, No. 4. pp. 628-632.
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