Polyol synthesis, functionalisation, and biocompatibility studies of superparamagnetic iron oxide nanoparticles as potential MRI contrast agents

Roxanne Hachani, Mark Lowdell, Martin Birchall, Aziliz Hervault, Damien Mertz, Sylvie Begin-Colin, Nguyn Thi B D Kim Thanh

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Iron oxide nanoparticles (IONPs) of low polydispersity were obtained through a simple polyol synthesis in high pressure and high temperature conditions. The control of the size and morphology of the nanoparticles was studied by varying the solvent used, the amount of iron precursor and the reaction time. Compared with conventional synthesis methods such as thermal decomposition or co-precipitation, this process yields nanoparticles with a narrow particle size distribution in a simple, reproducible and cost effective manner without the need for an inert atmosphere. For example, IONPs with a diameter of ca. 8 nm could be made in a reproducible manner and with good crystallinity as evidenced by X-ray diffraction analysis and high saturation magnetization value (84.5 emu g-1). The surface of the IONPs could be tailored post synthesis with two different ligands which provided functionality and stability in water and phosphate buffer saline (PBS). Their potential as a magnetic resonance imaging (MRI) contrast agent was confirmed as they exhibited high r1 and r2 relaxivities of 7.95 mM-1 s-1 and 185.58 mM-1 s-1 respectively at 1.4 T. Biocompatibility and viability of IONPs in primary human mesenchymal stem cells (hMSCs) was studied and confirmed.

Original languageEnglish (US)
Pages (from-to)3278-3287
Number of pages10
JournalNanoscale
Volume8
Issue number6
DOIs
StatePublished - Feb 14 2016
Externally publishedYes

Fingerprint

Polyols
Magnetic resonance
Iron oxides
Biocompatibility
Contrast Media
Nanoparticles
Imaging techniques
Polydispersity
Saturation magnetization
Coprecipitation
Stem cells
Particle size analysis
X ray diffraction analysis
ferric oxide
polyol
Buffers
Phosphates
Pyrolysis
Iron
Ligands

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Hachani, R., Lowdell, M., Birchall, M., Hervault, A., Mertz, D., Begin-Colin, S., & Thanh, N. T. B. D. K. (2016). Polyol synthesis, functionalisation, and biocompatibility studies of superparamagnetic iron oxide nanoparticles as potential MRI contrast agents. Nanoscale, 8(6), 3278-3287. https://doi.org/10.1039/c5nr03867g

Polyol synthesis, functionalisation, and biocompatibility studies of superparamagnetic iron oxide nanoparticles as potential MRI contrast agents. / Hachani, Roxanne; Lowdell, Mark; Birchall, Martin; Hervault, Aziliz; Mertz, Damien; Begin-Colin, Sylvie; Thanh, Nguyn Thi B D Kim.

In: Nanoscale, Vol. 8, No. 6, 14.02.2016, p. 3278-3287.

Research output: Contribution to journalArticle

Hachani, R, Lowdell, M, Birchall, M, Hervault, A, Mertz, D, Begin-Colin, S & Thanh, NTBDK 2016, 'Polyol synthesis, functionalisation, and biocompatibility studies of superparamagnetic iron oxide nanoparticles as potential MRI contrast agents', Nanoscale, vol. 8, no. 6, pp. 3278-3287. https://doi.org/10.1039/c5nr03867g
Hachani, Roxanne ; Lowdell, Mark ; Birchall, Martin ; Hervault, Aziliz ; Mertz, Damien ; Begin-Colin, Sylvie ; Thanh, Nguyn Thi B D Kim. / Polyol synthesis, functionalisation, and biocompatibility studies of superparamagnetic iron oxide nanoparticles as potential MRI contrast agents. In: Nanoscale. 2016 ; Vol. 8, No. 6. pp. 3278-3287.
@article{55894295169c4859afb04a6e8dc3d45c,
title = "Polyol synthesis, functionalisation, and biocompatibility studies of superparamagnetic iron oxide nanoparticles as potential MRI contrast agents",
abstract = "Iron oxide nanoparticles (IONPs) of low polydispersity were obtained through a simple polyol synthesis in high pressure and high temperature conditions. The control of the size and morphology of the nanoparticles was studied by varying the solvent used, the amount of iron precursor and the reaction time. Compared with conventional synthesis methods such as thermal decomposition or co-precipitation, this process yields nanoparticles with a narrow particle size distribution in a simple, reproducible and cost effective manner without the need for an inert atmosphere. For example, IONPs with a diameter of ca. 8 nm could be made in a reproducible manner and with good crystallinity as evidenced by X-ray diffraction analysis and high saturation magnetization value (84.5 emu g-1). The surface of the IONPs could be tailored post synthesis with two different ligands which provided functionality and stability in water and phosphate buffer saline (PBS). Their potential as a magnetic resonance imaging (MRI) contrast agent was confirmed as they exhibited high r1 and r2 relaxivities of 7.95 mM-1 s-1 and 185.58 mM-1 s-1 respectively at 1.4 T. Biocompatibility and viability of IONPs in primary human mesenchymal stem cells (hMSCs) was studied and confirmed.",
author = "Roxanne Hachani and Mark Lowdell and Martin Birchall and Aziliz Hervault and Damien Mertz and Sylvie Begin-Colin and Thanh, {Nguyn Thi B D Kim}",
year = "2016",
month = "2",
day = "14",
doi = "10.1039/c5nr03867g",
language = "English (US)",
volume = "8",
pages = "3278--3287",
journal = "Nanoscale",
issn = "2040-3364",
publisher = "Royal Society of Chemistry",
number = "6",

}

TY - JOUR

T1 - Polyol synthesis, functionalisation, and biocompatibility studies of superparamagnetic iron oxide nanoparticles as potential MRI contrast agents

AU - Hachani, Roxanne

AU - Lowdell, Mark

AU - Birchall, Martin

AU - Hervault, Aziliz

AU - Mertz, Damien

AU - Begin-Colin, Sylvie

AU - Thanh, Nguyn Thi B D Kim

PY - 2016/2/14

Y1 - 2016/2/14

N2 - Iron oxide nanoparticles (IONPs) of low polydispersity were obtained through a simple polyol synthesis in high pressure and high temperature conditions. The control of the size and morphology of the nanoparticles was studied by varying the solvent used, the amount of iron precursor and the reaction time. Compared with conventional synthesis methods such as thermal decomposition or co-precipitation, this process yields nanoparticles with a narrow particle size distribution in a simple, reproducible and cost effective manner without the need for an inert atmosphere. For example, IONPs with a diameter of ca. 8 nm could be made in a reproducible manner and with good crystallinity as evidenced by X-ray diffraction analysis and high saturation magnetization value (84.5 emu g-1). The surface of the IONPs could be tailored post synthesis with two different ligands which provided functionality and stability in water and phosphate buffer saline (PBS). Their potential as a magnetic resonance imaging (MRI) contrast agent was confirmed as they exhibited high r1 and r2 relaxivities of 7.95 mM-1 s-1 and 185.58 mM-1 s-1 respectively at 1.4 T. Biocompatibility and viability of IONPs in primary human mesenchymal stem cells (hMSCs) was studied and confirmed.

AB - Iron oxide nanoparticles (IONPs) of low polydispersity were obtained through a simple polyol synthesis in high pressure and high temperature conditions. The control of the size and morphology of the nanoparticles was studied by varying the solvent used, the amount of iron precursor and the reaction time. Compared with conventional synthesis methods such as thermal decomposition or co-precipitation, this process yields nanoparticles with a narrow particle size distribution in a simple, reproducible and cost effective manner without the need for an inert atmosphere. For example, IONPs with a diameter of ca. 8 nm could be made in a reproducible manner and with good crystallinity as evidenced by X-ray diffraction analysis and high saturation magnetization value (84.5 emu g-1). The surface of the IONPs could be tailored post synthesis with two different ligands which provided functionality and stability in water and phosphate buffer saline (PBS). Their potential as a magnetic resonance imaging (MRI) contrast agent was confirmed as they exhibited high r1 and r2 relaxivities of 7.95 mM-1 s-1 and 185.58 mM-1 s-1 respectively at 1.4 T. Biocompatibility and viability of IONPs in primary human mesenchymal stem cells (hMSCs) was studied and confirmed.

UR - http://www.scopus.com/inward/record.url?scp=84957673491&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84957673491&partnerID=8YFLogxK

U2 - 10.1039/c5nr03867g

DO - 10.1039/c5nr03867g

M3 - Article

VL - 8

SP - 3278

EP - 3287

JO - Nanoscale

JF - Nanoscale

SN - 2040-3364

IS - 6

ER -