Polyneuropathy in feline niemann-pick disease

Paul A. Cuddon, Robert Higgins, Ian D. Duncan, Stephen P.F. Miller, Joane M. Parent, Ann B. Moser

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Two related cats, aged 5 months and 7 months, and 1 unrelated cat, aged 4 months, presented with signs of a progressive neuromuscular disease. Detailed electrophysiological studies suggested a primary demyelinating polyneuropathy, which was confirmed by muscle and nerve biopsies and on necropsy examination. Light and electron microscopic findings indicated a lysosomal storage disease, which was diagnosed as sphingomyelinase deficiency (Niemann-Pick disease) by enzyme analysis and lipid fractionation, although significant biochemical differences existed between the 2 related cats and the third cat. Several lines of evidence suggest that these 2 related cats were affected with a variant of type. A Niemann-Pick disease, whereas cat 3 represented classic Niemann-Pick disease type A.

Original languageEnglish (US)
Pages (from-to)1429-1443
Number of pages15
JournalBrain
Volume112
Issue number6
DOIs
StatePublished - Dec 1 1989

Fingerprint

Niemann-Pick Diseases
Polyneuropathies
Felidae
Cats
Type A Niemann-Pick Disease
Lysosomal Storage Diseases
Neuromuscular Diseases
Electrons
Lipids
Biopsy
Light
Muscles
Enzymes

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Cuddon, P. A., Higgins, R., Duncan, I. D., Miller, S. P. F., Parent, J. M., & Moser, A. B. (1989). Polyneuropathy in feline niemann-pick disease. Brain, 112(6), 1429-1443. https://doi.org/10.1093/brain/112.6.1429

Polyneuropathy in feline niemann-pick disease. / Cuddon, Paul A.; Higgins, Robert; Duncan, Ian D.; Miller, Stephen P.F.; Parent, Joane M.; Moser, Ann B.

In: Brain, Vol. 112, No. 6, 01.12.1989, p. 1429-1443.

Research output: Contribution to journalArticle

Cuddon, PA, Higgins, R, Duncan, ID, Miller, SPF, Parent, JM & Moser, AB 1989, 'Polyneuropathy in feline niemann-pick disease', Brain, vol. 112, no. 6, pp. 1429-1443. https://doi.org/10.1093/brain/112.6.1429
Cuddon PA, Higgins R, Duncan ID, Miller SPF, Parent JM, Moser AB. Polyneuropathy in feline niemann-pick disease. Brain. 1989 Dec 1;112(6):1429-1443. https://doi.org/10.1093/brain/112.6.1429
Cuddon, Paul A. ; Higgins, Robert ; Duncan, Ian D. ; Miller, Stephen P.F. ; Parent, Joane M. ; Moser, Ann B. / Polyneuropathy in feline niemann-pick disease. In: Brain. 1989 ; Vol. 112, No. 6. pp. 1429-1443.
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