Polymorphisms of genes encoding phase I enzymes in Mexican Americans - An ethnic comparison study

Huai Rong Luo, Yu-Jui Yvonne Wan

Research output: Contribution to journalArticle

Abstract

The inter-individual and inter-ethnic variations in phase I enzyme activity is largely attributed to gene polymorphisms. The distribution and clinical consequences of these variations have been extensively studied in Africans, Asians, and Caucasians. However, information is still lacking regarding the frequency and the impact of these variations on xenobiotic metabolism and disease processes in Mexican Americans. Therefore, this review addresses the polymorphisms of genes encoding phase I enzymes in Mexican Americans; these include: cytochrome P450 (CYP) 2C19, CYP2D6, CYP2E1, alcohol dehydrogenase (ADH), and aldehyde dehydrogenase (ALDH). This review article summarizes the association between phenotype (drug metabolism) and genotype for CYP2C19 and CYP2D6 as well as the role of genetic variations in CYP2E1, ADH, and ALDH as potential risk factors for alcoholism in the Mexican American population. The major findings are as follows: (1) Mexican Americans have unique genetic patterns compared with other ethnic groups; (2) In general, Mexican Americans tend to be extensive metabolizers of substrates for CYP2C19 and CYP2D6; (3) Genotypes of CYP2D6 can be used to predict phenotypes in Mexican Americans; and (4) Variations in alcohol metabolizing genes contribute to alcoholism in the Mexican American population.

Original languageEnglish (US)
Pages (from-to)345-353
Number of pages9
JournalCurrent Pharmacogenomics
Volume4
Issue number4
DOIs
StatePublished - Dec 2006
Externally publishedYes

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Keywords

  • ADH
  • Alcoholism
  • ALDH
  • CYP2C19
  • CYP2D6
  • CYP2E1
  • Genotype
  • Mexican Americans
  • Pharmacogenomics
  • Phenotype

ASJC Scopus subject areas

  • Pharmacology
  • Genetics

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