Polygonum multiflorum Decreases Airway Allergic Symptoms in a Murine Model of Asthma

Chen Chen Lee, Yueh Lun Lee, Chien N. Wang, Hsing Chuan Tsai, Chun Lung Chiu, Leroy F. Liu, Hung Yun Lin, Reen Wu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The root of Polygonum multiflorum (also called He-Shou-Wu in Chinese) is a common herb and medicinal food in Asia used for its anti-aging properties. Our study investigated the therapeutic potential of an extract of the root of Polygonum multiflorum (PME) in allergic asthma by using a mouse model. Feeding of 0.5 and 1 mg/mouse PME inhibited ovalbumin (OVA)-induced allergic asthma symptoms, including airway inflammation, mucus production, and airway hyper-responsiveness (AHR), in a dose-dependent manner. To discern PME's mechanism of action, we examined the profile and cytokine production of inflammatory cells in bronchial alveolar lavage fluid (BALF). We found that eosinophils, the main inflammatory cell infiltrate in the lung of OVA-immunized mice, significantly decreased after PME treatment. Th2 cytokine levels, including interleukin (IL)-4, IL-5, IL-13, eotaxin, and the proinflammatory cytokine tumor necrosis factor (TNF)-α, decreased in PME-treated mice. Elevated mRNA expression of Th2 transcription factor GATA-3 in the lung tissue was also inhibited after oral feeding of PME in OVA-immunized mice. Thus, we conclude that PME produces anti-asthma activity through the inhibition of Th2 cell activation.

Original languageEnglish (US)
Pages (from-to)133-147
Number of pages15
JournalAmerican Journal of Chinese Medicine
Volume44
Issue number1
DOIs
StatePublished - Feb 1 2016

Fingerprint

Asthma
Ovalbumin
Cytokines
Respiratory Hypersensitivity
Transcription Factor 3
Lung
Th2 Cells
Interleukin-13
Interleukin-5
Bronchoalveolar Lavage Fluid
Mucus
Medicinal Plants
Eosinophils
Interleukin-4
Tumor Necrosis Factor-alpha
Fallopia multiflora
Inflammation
Food
Messenger RNA
Therapeutics

Keywords

  • Airway Hyper-Responsiveness
  • Airway Inflammation
  • Polygonum multiflorum
  • Th2

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Polygonum multiflorum Decreases Airway Allergic Symptoms in a Murine Model of Asthma. / Lee, Chen Chen; Lee, Yueh Lun; Wang, Chien N.; Tsai, Hsing Chuan; Chiu, Chun Lung; Liu, Leroy F.; Lin, Hung Yun; Wu, Reen.

In: American Journal of Chinese Medicine, Vol. 44, No. 1, 01.02.2016, p. 133-147.

Research output: Contribution to journalArticle

Lee, Chen Chen ; Lee, Yueh Lun ; Wang, Chien N. ; Tsai, Hsing Chuan ; Chiu, Chun Lung ; Liu, Leroy F. ; Lin, Hung Yun ; Wu, Reen. / Polygonum multiflorum Decreases Airway Allergic Symptoms in a Murine Model of Asthma. In: American Journal of Chinese Medicine. 2016 ; Vol. 44, No. 1. pp. 133-147.
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