Abstract
Polycystic liver is usually considered an incidental finding in human and veterinary medicine. Two unrelated adult llamas (Lama glama) with a history of marked anorexia and weight loss were received for autopsy and diagnostic workup. The main gross change in the liver of both animals was multiple variably sized cysts randomly distributed throughout the parenchyma. Histologically, the cysts compressed the adjacent parenchyma and were lined by a single layer of cuboidal-to-columnar epithelium, surrounded by a fibrous collagen capsule. The lumen of the cysts contained finely granular-to-homogeneous basophilic material. The lining epithelium displayed strong immunoreactivity for pancytokeratin AE1/AE3 and cytokeratins 7, 8, 8/18, and 19, and was negative for vimentin, confirming the biliary epithelial origin of the cysts. No parasitic or infectious agents, or neoplastic changes, were detected. All other laboratory tests performed in both llamas were negative or non-diagnostic, suggesting that the congenital hepatic cysts described may have been at least partly responsible for clinical disease in both animals.
| Original language | English (US) |
|---|---|
| Journal | Journal of Veterinary Diagnostic Investigation |
| DOIs | |
| State | Accepted/In press - Jan 1 2019 |
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Keywords
- Congenital hepatic cysts
- liver disease
- llamas
ASJC Scopus subject areas
- veterinary(all)
Cite this
Polycystic liver in two adult llamas. / Watanabe, Tatiane T.Negrão; Carvallo Chaigneau, Francisco R; Adaska, John M; Doncel-Díaz, Benjamín; Uzal, Francisco A.
In: Journal of Veterinary Diagnostic Investigation, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Polycystic liver in two adult llamas
AU - Watanabe, Tatiane T.Negrão
AU - Carvallo Chaigneau, Francisco R
AU - Adaska, John M
AU - Doncel-Díaz, Benjamín
AU - Uzal, Francisco A
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Polycystic liver is usually considered an incidental finding in human and veterinary medicine. Two unrelated adult llamas (Lama glama) with a history of marked anorexia and weight loss were received for autopsy and diagnostic workup. The main gross change in the liver of both animals was multiple variably sized cysts randomly distributed throughout the parenchyma. Histologically, the cysts compressed the adjacent parenchyma and were lined by a single layer of cuboidal-to-columnar epithelium, surrounded by a fibrous collagen capsule. The lumen of the cysts contained finely granular-to-homogeneous basophilic material. The lining epithelium displayed strong immunoreactivity for pancytokeratin AE1/AE3 and cytokeratins 7, 8, 8/18, and 19, and was negative for vimentin, confirming the biliary epithelial origin of the cysts. No parasitic or infectious agents, or neoplastic changes, were detected. All other laboratory tests performed in both llamas were negative or non-diagnostic, suggesting that the congenital hepatic cysts described may have been at least partly responsible for clinical disease in both animals.
AB - Polycystic liver is usually considered an incidental finding in human and veterinary medicine. Two unrelated adult llamas (Lama glama) with a history of marked anorexia and weight loss were received for autopsy and diagnostic workup. The main gross change in the liver of both animals was multiple variably sized cysts randomly distributed throughout the parenchyma. Histologically, the cysts compressed the adjacent parenchyma and were lined by a single layer of cuboidal-to-columnar epithelium, surrounded by a fibrous collagen capsule. The lumen of the cysts contained finely granular-to-homogeneous basophilic material. The lining epithelium displayed strong immunoreactivity for pancytokeratin AE1/AE3 and cytokeratins 7, 8, 8/18, and 19, and was negative for vimentin, confirming the biliary epithelial origin of the cysts. No parasitic or infectious agents, or neoplastic changes, were detected. All other laboratory tests performed in both llamas were negative or non-diagnostic, suggesting that the congenital hepatic cysts described may have been at least partly responsible for clinical disease in both animals.
KW - Congenital hepatic cysts
KW - liver disease
KW - llamas
UR - http://www.scopus.com/inward/record.url?scp=85060578866&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85060578866&partnerID=8YFLogxK
U2 - 10.1177/1040638718824736
DO - 10.1177/1040638718824736
M3 - Article
C2 - 30661455
AN - SCOPUS:85060578866
JO - Journal of Veterinary Diagnostic Investigation
JF - Journal of Veterinary Diagnostic Investigation
SN - 1040-6387
ER -