Polyclonal gammopathies associated with chronic diseases in nonhuman primates.

Bennie Osburn, C. A. Holmberg, T. G. Terrell, J. Codington, K. Greeley, R. V. Henrickson

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Serum samples collected from clinically healthy rhesus macaques (Macaca mulatta) were compared with serums from animals diagnosed as having malignant lymphoma, atypical tuberculosis, progressive multifocal leukoencephalopathy, or more than 1 of these. Electrophoretic analyses of serum proteins (in grams per deciliter) indicated that mean values in a clinically normal group were as follows--total protein, 8.30; albumin, 4.07; alpha-globulin, 0.85; beta-globulin, 2.23; and gamma-globulin, 1.15. In macaques with malignant lymphoma, mean values were--total protein, 7.60; albumin, 2.72; alpha-globulin, 0.91; beta-globulin, 1.71; and gamma-globulin, 2.23. In macaques with atypical tuberculosis, these values were 8.47, 2.92, 0.84, 2.18, and 2.52, respectively, and those with progressive multifocal leukoencephalopathy, 9.06, 4.01, 6.71, 2.42, and 1.93. Where multiple serum samples were available from 1 macaque for analysis, gamma-globulin values were increased before clinical disease was apparent. Evaluation of serums from macaques may be used as a means of detecting preclinical lymphoproliferative disease.

Original languageEnglish (US)
Pages (from-to)671-674
Number of pages4
JournalAmerican Journal of Veterinary Research
Volume38
Issue number5
StatePublished - May 1 1977
Externally publishedYes

Fingerprint

Macaca
chronic diseases
Primates
gamma-globulins
gamma-Globulins
Chronic Disease
Beta-Globulins
Alpha-Globulins
alpha-globulins
Progressive Multifocal Leukoencephalopathy
Macaca mulatta
lymphoma
Serum
tuberculosis
albumins
Albumins
Lymphoma
Tuberculosis
normal values
blood proteins

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Osburn, B., Holmberg, C. A., Terrell, T. G., Codington, J., Greeley, K., & Henrickson, R. V. (1977). Polyclonal gammopathies associated with chronic diseases in nonhuman primates. American Journal of Veterinary Research, 38(5), 671-674.

Polyclonal gammopathies associated with chronic diseases in nonhuman primates. / Osburn, Bennie; Holmberg, C. A.; Terrell, T. G.; Codington, J.; Greeley, K.; Henrickson, R. V.

In: American Journal of Veterinary Research, Vol. 38, No. 5, 01.05.1977, p. 671-674.

Research output: Contribution to journalArticle

Osburn, B, Holmberg, CA, Terrell, TG, Codington, J, Greeley, K & Henrickson, RV 1977, 'Polyclonal gammopathies associated with chronic diseases in nonhuman primates.', American Journal of Veterinary Research, vol. 38, no. 5, pp. 671-674.
Osburn B, Holmberg CA, Terrell TG, Codington J, Greeley K, Henrickson RV. Polyclonal gammopathies associated with chronic diseases in nonhuman primates. American Journal of Veterinary Research. 1977 May 1;38(5):671-674.
Osburn, Bennie ; Holmberg, C. A. ; Terrell, T. G. ; Codington, J. ; Greeley, K. ; Henrickson, R. V. / Polyclonal gammopathies associated with chronic diseases in nonhuman primates. In: American Journal of Veterinary Research. 1977 ; Vol. 38, No. 5. pp. 671-674.
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