Polychlorinated biphenyls and their hydroxylated metabolites (OH-PCBs) in pregnant women from eastern Slovakia

June Soo Park, Linda Linderholm, M. Judith Charles, Maria Athanasiadou, Jan Petrik, Anton Kocan, Beata Drobna, Tomas Trnovec, Åke Bergman, Irva Hertz-Picciotto

Research output: Contribution to journalArticle

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Abstract

Objective: Our aim in the present study was to characterize and quantify the levels of polychlorinated biphenyls (PCBs) and specific polychlorobiphenylol (OH-PCB) metabolites in maternal sera from women delivering in eastern Slovakia. Design: During 2002-2004, blood samples were collected from women delivering in two Slovak locations: Michalovce district, where PCBs were formerly manufactured, and Svidnik and Stropkov districts, about 70 km north. Participants: A total of 762 and 341 pregnant women were sampled from Michalovce and Svidnik/Stropkov, respectively, and OH-PCBs were measured in 131 and 31. Evaluation/Measurements: We analyzed PCBs using gas chromatography (GC)/electron capture detection. OH-PCBs and pentachlorophenol (PCP) were determined as methyl derivatives using GC-electron capture negative ionization/mass spectrometry. We characterized distributions in the full cohort using inverse sampling weights. Results: The concentrations of both PCBs and OH-PCB metabolites of Michalovce mothers were about two times higher than those of the Svidnik/Stropkov mothers (p < 0.001). The median weighted maternal serum levels of the sum of PCBs (∑PCBs) were 5.73 ng/g wet weight (Michalovce) and 2.82 ng/g wet weight (Svidnik/Stropkov). The median sum of OH-PCBs (∑OH-PCBs) was 0.55 ng/g wet weight in Michalovce mothers and 0.32 ng/ g wet weight in Svidnik/Stropkov mothers. 4-OH-2,2′,3,4′,5,5′,6-Heptachlorobiphenyl (4-OH-CB187) was a primary metabolite, followed by 4-OH-2,2′,3,4′,5,5′-hexachlorobiphenyl (4-OH-CB146). Only four PCB congeners - CBs 153, 138, 180, and 170 - had higher concentrations than 4-OH-CB187 and 4-OH-CB146 (p < 0.001). The median ratio of the ∑OH-PCBs to the ∑PCBs was 0.10. Conclusions: Mothers residing in eastern Slovakia are still highly exposed to PCBs, and their body burdens of these pollutants and OH-PCB metabolites may pose a risk for adverse effects on health for themselves and their children.

Original languageEnglish (US)
Pages (from-to)20-27
Number of pages8
JournalEnvironmental Health Perspectives
Volume115
Issue number1
DOIs
StatePublished - Jan 2007

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Slovakia
Polychlorinated Biphenyls
Metabolites
Pregnant Women
PCB
metabolite
Mothers
Weights and Measures
hydroxide ion
woman
2,4,5,2',4',5'-hexachlorobiphenyl
Gas chromatography
Gas Chromatography
serum
gas chromatography
Electrons
Pentachlorophenol
Body Burden
electron
PCP

Keywords

  • Hydroxylated PCB metabolites
  • Maternal blood serum
  • OH-PCBs
  • PCBs
  • PCP
  • Pentachlorophenol
  • Polychlorinated biphenyls
  • Slovakia

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Polychlorinated biphenyls and their hydroxylated metabolites (OH-PCBs) in pregnant women from eastern Slovakia. / Park, June Soo; Linderholm, Linda; Charles, M. Judith; Athanasiadou, Maria; Petrik, Jan; Kocan, Anton; Drobna, Beata; Trnovec, Tomas; Bergman, Åke; Hertz-Picciotto, Irva.

In: Environmental Health Perspectives, Vol. 115, No. 1, 01.2007, p. 20-27.

Research output: Contribution to journalArticle

Park, JS, Linderholm, L, Charles, MJ, Athanasiadou, M, Petrik, J, Kocan, A, Drobna, B, Trnovec, T, Bergman, Å & Hertz-Picciotto, I 2007, 'Polychlorinated biphenyls and their hydroxylated metabolites (OH-PCBs) in pregnant women from eastern Slovakia', Environmental Health Perspectives, vol. 115, no. 1, pp. 20-27. https://doi.org/10.1289/ehp.8913
Park, June Soo ; Linderholm, Linda ; Charles, M. Judith ; Athanasiadou, Maria ; Petrik, Jan ; Kocan, Anton ; Drobna, Beata ; Trnovec, Tomas ; Bergman, Åke ; Hertz-Picciotto, Irva. / Polychlorinated biphenyls and their hydroxylated metabolites (OH-PCBs) in pregnant women from eastern Slovakia. In: Environmental Health Perspectives. 2007 ; Vol. 115, No. 1. pp. 20-27.
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T1 - Polychlorinated biphenyls and their hydroxylated metabolites (OH-PCBs) in pregnant women from eastern Slovakia

AU - Park, June Soo

AU - Linderholm, Linda

AU - Charles, M. Judith

AU - Athanasiadou, Maria

AU - Petrik, Jan

AU - Kocan, Anton

AU - Drobna, Beata

AU - Trnovec, Tomas

AU - Bergman, Åke

AU - Hertz-Picciotto, Irva

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N2 - Objective: Our aim in the present study was to characterize and quantify the levels of polychlorinated biphenyls (PCBs) and specific polychlorobiphenylol (OH-PCB) metabolites in maternal sera from women delivering in eastern Slovakia. Design: During 2002-2004, blood samples were collected from women delivering in two Slovak locations: Michalovce district, where PCBs were formerly manufactured, and Svidnik and Stropkov districts, about 70 km north. Participants: A total of 762 and 341 pregnant women were sampled from Michalovce and Svidnik/Stropkov, respectively, and OH-PCBs were measured in 131 and 31. Evaluation/Measurements: We analyzed PCBs using gas chromatography (GC)/electron capture detection. OH-PCBs and pentachlorophenol (PCP) were determined as methyl derivatives using GC-electron capture negative ionization/mass spectrometry. We characterized distributions in the full cohort using inverse sampling weights. Results: The concentrations of both PCBs and OH-PCB metabolites of Michalovce mothers were about two times higher than those of the Svidnik/Stropkov mothers (p < 0.001). The median weighted maternal serum levels of the sum of PCBs (∑PCBs) were 5.73 ng/g wet weight (Michalovce) and 2.82 ng/g wet weight (Svidnik/Stropkov). The median sum of OH-PCBs (∑OH-PCBs) was 0.55 ng/g wet weight in Michalovce mothers and 0.32 ng/ g wet weight in Svidnik/Stropkov mothers. 4-OH-2,2′,3,4′,5,5′,6-Heptachlorobiphenyl (4-OH-CB187) was a primary metabolite, followed by 4-OH-2,2′,3,4′,5,5′-hexachlorobiphenyl (4-OH-CB146). Only four PCB congeners - CBs 153, 138, 180, and 170 - had higher concentrations than 4-OH-CB187 and 4-OH-CB146 (p < 0.001). The median ratio of the ∑OH-PCBs to the ∑PCBs was 0.10. Conclusions: Mothers residing in eastern Slovakia are still highly exposed to PCBs, and their body burdens of these pollutants and OH-PCB metabolites may pose a risk for adverse effects on health for themselves and their children.

AB - Objective: Our aim in the present study was to characterize and quantify the levels of polychlorinated biphenyls (PCBs) and specific polychlorobiphenylol (OH-PCB) metabolites in maternal sera from women delivering in eastern Slovakia. Design: During 2002-2004, blood samples were collected from women delivering in two Slovak locations: Michalovce district, where PCBs were formerly manufactured, and Svidnik and Stropkov districts, about 70 km north. Participants: A total of 762 and 341 pregnant women were sampled from Michalovce and Svidnik/Stropkov, respectively, and OH-PCBs were measured in 131 and 31. Evaluation/Measurements: We analyzed PCBs using gas chromatography (GC)/electron capture detection. OH-PCBs and pentachlorophenol (PCP) were determined as methyl derivatives using GC-electron capture negative ionization/mass spectrometry. We characterized distributions in the full cohort using inverse sampling weights. Results: The concentrations of both PCBs and OH-PCB metabolites of Michalovce mothers were about two times higher than those of the Svidnik/Stropkov mothers (p < 0.001). The median weighted maternal serum levels of the sum of PCBs (∑PCBs) were 5.73 ng/g wet weight (Michalovce) and 2.82 ng/g wet weight (Svidnik/Stropkov). The median sum of OH-PCBs (∑OH-PCBs) was 0.55 ng/g wet weight in Michalovce mothers and 0.32 ng/ g wet weight in Svidnik/Stropkov mothers. 4-OH-2,2′,3,4′,5,5′,6-Heptachlorobiphenyl (4-OH-CB187) was a primary metabolite, followed by 4-OH-2,2′,3,4′,5,5′-hexachlorobiphenyl (4-OH-CB146). Only four PCB congeners - CBs 153, 138, 180, and 170 - had higher concentrations than 4-OH-CB187 and 4-OH-CB146 (p < 0.001). The median ratio of the ∑OH-PCBs to the ∑PCBs was 0.10. Conclusions: Mothers residing in eastern Slovakia are still highly exposed to PCBs, and their body burdens of these pollutants and OH-PCB metabolites may pose a risk for adverse effects on health for themselves and their children.

KW - Hydroxylated PCB metabolites

KW - Maternal blood serum

KW - OH-PCBs

KW - PCBs

KW - PCP

KW - Pentachlorophenol

KW - Polychlorinated biphenyls

KW - Slovakia

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