Polybrominated diphenyl ether serum concentrations in a Californian population of children, their parents, and older adults: An exposure assessment study

Xiangmei Wu, Deborah H Bennett, Rebecca E. Moran, Andreas Sjödin, Richard S. Jones, Daniel J Tancredi, Nicolle S. Tulve, Matthew Scott Clifton, Maribel Colón, Walter Weathers, Irva Hertz-Picciotto

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in many household items. Given concerns over their potential adverse health effects, we identified predictors and evaluated temporal changes of PBDE serum concentrations. Methods: PBDE serum concentrations were measured in young children (2-8 years old; N∈=∈67), parents of young children (<55 years old; N∈=∈90), and older adults (=55 years old; N∈=∈59) in California, with concurrent floor wipe samples collected in participants' homes in 2008-2009. We also measured serum concentrations one year later in a subset of children (N∈=∈19) and parents (N∈=∈42). Results: PBDE serum concentrations in children were significantly higher than in adults. Floor wipe concentration is a significant predictor of serum BDE-47, 99, 100 and 154. Positive associations were observed between the intake frequency of canned meat and serum concentrations of BDE-47, 99 and 154, between canned meat entrees and BDE-154 and 209, as well as between tuna and white fish and BDE-153. The model with the floor wipe concentration and food intake frequencies explained up to 40% of the mean square prediction error of some congeners. Lower home values and renting (vs. owning) a home were associated with higher serum concentrations of BDE-47, 99 and 100. Serum concentrations measured one year apart were strongly correlated as expected (r∈=∈0.70-0.97) with a slight decreasing trend. Conclusions: Floor wipe concentration, food intake frequency, and housing characteristics can explain 12-40% of the prediction error of PBDE serum concentrations. Decreasing temporal trends should be considered when characterizing long-term exposure.

Original languageEnglish (US)
Article number23
JournalEnvironmental Health: A Global Access Science Source
Volume14
Issue number1
DOIs
StatePublished - 2015

Fingerprint

Halogenated Diphenyl Ethers
Parents
Serum
Population
decabromobiphenyl ether
Meat
Eating
Flame Retardants
Tuna
Fishes

Keywords

  • Children
  • Flame retardants
  • PBDEs
  • Serum concentration
  • Temporal variability

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Polybrominated diphenyl ether serum concentrations in a Californian population of children, their parents, and older adults : An exposure assessment study. / Wu, Xiangmei; Bennett, Deborah H; Moran, Rebecca E.; Sjödin, Andreas; Jones, Richard S.; Tancredi, Daniel J; Tulve, Nicolle S.; Clifton, Matthew Scott; Colón, Maribel; Weathers, Walter; Hertz-Picciotto, Irva.

In: Environmental Health: A Global Access Science Source, Vol. 14, No. 1, 23, 2015.

Research output: Contribution to journalArticle

Wu, Xiangmei ; Bennett, Deborah H ; Moran, Rebecca E. ; Sjödin, Andreas ; Jones, Richard S. ; Tancredi, Daniel J ; Tulve, Nicolle S. ; Clifton, Matthew Scott ; Colón, Maribel ; Weathers, Walter ; Hertz-Picciotto, Irva. / Polybrominated diphenyl ether serum concentrations in a Californian population of children, their parents, and older adults : An exposure assessment study. In: Environmental Health: A Global Access Science Source. 2015 ; Vol. 14, No. 1.
@article{98e7e2a5ea1a401492b24d602616b19a,
title = "Polybrominated diphenyl ether serum concentrations in a Californian population of children, their parents, and older adults: An exposure assessment study",
abstract = "Background: Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in many household items. Given concerns over their potential adverse health effects, we identified predictors and evaluated temporal changes of PBDE serum concentrations. Methods: PBDE serum concentrations were measured in young children (2-8 years old; N∈=∈67), parents of young children (<55 years old; N∈=∈90), and older adults (=55 years old; N∈=∈59) in California, with concurrent floor wipe samples collected in participants' homes in 2008-2009. We also measured serum concentrations one year later in a subset of children (N∈=∈19) and parents (N∈=∈42). Results: PBDE serum concentrations in children were significantly higher than in adults. Floor wipe concentration is a significant predictor of serum BDE-47, 99, 100 and 154. Positive associations were observed between the intake frequency of canned meat and serum concentrations of BDE-47, 99 and 154, between canned meat entrees and BDE-154 and 209, as well as between tuna and white fish and BDE-153. The model with the floor wipe concentration and food intake frequencies explained up to 40{\%} of the mean square prediction error of some congeners. Lower home values and renting (vs. owning) a home were associated with higher serum concentrations of BDE-47, 99 and 100. Serum concentrations measured one year apart were strongly correlated as expected (r∈=∈0.70-0.97) with a slight decreasing trend. Conclusions: Floor wipe concentration, food intake frequency, and housing characteristics can explain 12-40{\%} of the prediction error of PBDE serum concentrations. Decreasing temporal trends should be considered when characterizing long-term exposure.",
keywords = "Children, Flame retardants, PBDEs, Serum concentration, Temporal variability",
author = "Xiangmei Wu and Bennett, {Deborah H} and Moran, {Rebecca E.} and Andreas Sj{\"o}din and Jones, {Richard S.} and Tancredi, {Daniel J} and Tulve, {Nicolle S.} and Clifton, {Matthew Scott} and Maribel Col{\'o}n and Walter Weathers and Irva Hertz-Picciotto",
year = "2015",
doi = "10.1186/s12940-015-0002-2",
language = "English (US)",
volume = "14",
journal = "Environmental Health: A Global Access Science Source",
issn = "1476-069X",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Polybrominated diphenyl ether serum concentrations in a Californian population of children, their parents, and older adults

T2 - An exposure assessment study

AU - Wu, Xiangmei

AU - Bennett, Deborah H

AU - Moran, Rebecca E.

AU - Sjödin, Andreas

AU - Jones, Richard S.

AU - Tancredi, Daniel J

AU - Tulve, Nicolle S.

AU - Clifton, Matthew Scott

AU - Colón, Maribel

AU - Weathers, Walter

AU - Hertz-Picciotto, Irva

PY - 2015

Y1 - 2015

N2 - Background: Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in many household items. Given concerns over their potential adverse health effects, we identified predictors and evaluated temporal changes of PBDE serum concentrations. Methods: PBDE serum concentrations were measured in young children (2-8 years old; N∈=∈67), parents of young children (<55 years old; N∈=∈90), and older adults (=55 years old; N∈=∈59) in California, with concurrent floor wipe samples collected in participants' homes in 2008-2009. We also measured serum concentrations one year later in a subset of children (N∈=∈19) and parents (N∈=∈42). Results: PBDE serum concentrations in children were significantly higher than in adults. Floor wipe concentration is a significant predictor of serum BDE-47, 99, 100 and 154. Positive associations were observed between the intake frequency of canned meat and serum concentrations of BDE-47, 99 and 154, between canned meat entrees and BDE-154 and 209, as well as between tuna and white fish and BDE-153. The model with the floor wipe concentration and food intake frequencies explained up to 40% of the mean square prediction error of some congeners. Lower home values and renting (vs. owning) a home were associated with higher serum concentrations of BDE-47, 99 and 100. Serum concentrations measured one year apart were strongly correlated as expected (r∈=∈0.70-0.97) with a slight decreasing trend. Conclusions: Floor wipe concentration, food intake frequency, and housing characteristics can explain 12-40% of the prediction error of PBDE serum concentrations. Decreasing temporal trends should be considered when characterizing long-term exposure.

AB - Background: Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in many household items. Given concerns over their potential adverse health effects, we identified predictors and evaluated temporal changes of PBDE serum concentrations. Methods: PBDE serum concentrations were measured in young children (2-8 years old; N∈=∈67), parents of young children (<55 years old; N∈=∈90), and older adults (=55 years old; N∈=∈59) in California, with concurrent floor wipe samples collected in participants' homes in 2008-2009. We also measured serum concentrations one year later in a subset of children (N∈=∈19) and parents (N∈=∈42). Results: PBDE serum concentrations in children were significantly higher than in adults. Floor wipe concentration is a significant predictor of serum BDE-47, 99, 100 and 154. Positive associations were observed between the intake frequency of canned meat and serum concentrations of BDE-47, 99 and 154, between canned meat entrees and BDE-154 and 209, as well as between tuna and white fish and BDE-153. The model with the floor wipe concentration and food intake frequencies explained up to 40% of the mean square prediction error of some congeners. Lower home values and renting (vs. owning) a home were associated with higher serum concentrations of BDE-47, 99 and 100. Serum concentrations measured one year apart were strongly correlated as expected (r∈=∈0.70-0.97) with a slight decreasing trend. Conclusions: Floor wipe concentration, food intake frequency, and housing characteristics can explain 12-40% of the prediction error of PBDE serum concentrations. Decreasing temporal trends should be considered when characterizing long-term exposure.

KW - Children

KW - Flame retardants

KW - PBDEs

KW - Serum concentration

KW - Temporal variability

UR - http://www.scopus.com/inward/record.url?scp=84961289492&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961289492&partnerID=8YFLogxK

U2 - 10.1186/s12940-015-0002-2

DO - 10.1186/s12940-015-0002-2

M3 - Article

C2 - 25884939

AN - SCOPUS:84961289492

VL - 14

JO - Environmental Health: A Global Access Science Source

JF - Environmental Health: A Global Access Science Source

SN - 1476-069X

IS - 1

M1 - 23

ER -