Polybrominated diphenyl ether (PBDE)-induced alterations in vitamin A and thyroid hormone concentrations in the rat during lactation and early postnatal development

Robert G. Ellis-Hutchings, Gary N. Cherr, Lynn A. Hanna, Carl L Keen

Research output: Contribution to journalArticle

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Abstract

In experimental animals fed standard laboratory diets, penta-BDE mixtures can decrease circulating thyroid hormone and liver vitamin A concentrations. A substantial number of pregnant women and their children have marginal vitamin A status, potentially increasing their risk of adverse effects to penta-BDE exposure. The current study investigated the effects of maternal gestational and lactational penta-BDE exposure on thyroid hormone and vitamin A homeostasis in rats of sufficient vitamin A (VAS) or marginal vitamin A (VAM) status and their offspring. Dams were administered daily oral doses of 18 mg/kg DE-71 (a penta-BDE mixture) or a corn oil vehicle from gestation day 6 through lactation day (LD) 18. Thyroid hormone and vitamin A homeostasis were assessed in plasma and tissues of LD 19 dams and postnatal day (PND) 12, 18, and 31 pups. DE-71 exposure induced hepatomegaly in VAS and VAM pups at all timepoints and increased testes weights at PND 31. While liver vitamin A concentrations were low in DE-71 treated dams and pups, plasma retinol concentrations and plasma retinol binding protein levels were only low in VAM animals exposed to DE-71. DE-71 exposure lowered plasma thyroxine concentrations in VAS and VAM dams and pups. Plasma thyroid stimulating hormone concentrations were high in VAM dams exposed to DE-71, suggesting that marginal vitamin A status enhances the susceptibility to thyroid hormone axis disruption by DE-71. These results support the concept that marginal vitamin A status in pregnant women may increase the risk for PBDE-induced disruptions in vitamin A and thyroid hormone homeostasis.

Original languageEnglish (US)
Pages (from-to)135-145
Number of pages11
JournalToxicology and Applied Pharmacology
Volume215
Issue number2
DOIs
StatePublished - Sep 1 2006

Fingerprint

Halogenated Diphenyl Ethers
Vitamin A
Thyroid Hormones
Lactation
Rats
Rubiaceae
Dams
Plasmas
Homeostasis
Liver
Pregnant Women
Plasma Retinol-Binding Proteins
Animals
Corn Oil
Hepatomegaly

Keywords

  • Marginal vitamin A status
  • PBDE
  • Penta-BDE mixtures
  • Retinol binding protein
  • Thyroid hormones
  • Thyroid stimulating hormone
  • Vitamin A homeostasis

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Polybrominated diphenyl ether (PBDE)-induced alterations in vitamin A and thyroid hormone concentrations in the rat during lactation and early postnatal development. / Ellis-Hutchings, Robert G.; Cherr, Gary N.; Hanna, Lynn A.; Keen, Carl L.

In: Toxicology and Applied Pharmacology, Vol. 215, No. 2, 01.09.2006, p. 135-145.

Research output: Contribution to journalArticle

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