Abstract
EM9 is a mutagen-sensitive CHO cell whose phenotype resembles that of normal CHO cells exposed to 3-aminobenzamide, an inhibitor of poly(ADP-ribose) synthesis. This phenotype suggested that EM9 might be defective in poly(ADP-ribose) metabolism, but we now cannot find any abnormality in the synthesis or in the degradation of poly(ADP-ribose) in permeabilized EM9 cells. Thus the effects of 3-aminobenzamide on wild-type cells may be due to the inhibition of processes other than poly(ADP-ribose) synthesis. 3-Aminobenzamide enhances the cytotoxicity of EMS toward EM9 and control cells to the same degree.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 213-220 |
| Number of pages | 8 |
| Journal | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis |
| Volume | 128 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1984 |
| Externally published | Yes |
ASJC Scopus subject areas
- Molecular Biology
- Health, Toxicology and Mutagenesis
- Medicine(all)
Fingerprint Dive into the research topics of 'Poly(ADP-ribose) metabolism appears normal in EM9, a mutagen-sensitive mutant of CHO cells'. Together they form a unique fingerprint.
Cite this
Ikejima, M., Bohannon, D., Michael Gill, D., & Thompson, L. H. (1984). Poly(ADP-ribose) metabolism appears normal in EM9, a mutagen-sensitive mutant of CHO cells. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 128(2), 213-220. https://doi.org/10.1016/0027-5107(84)90109-X