Polarimetric imaging of amyloid

Werner Kaminksy, Lee-Way Jin, Steven Powell, Izumi Maezawa, Kacey Claborn, Charles Branham, Bart Kahr

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

New developments in optical microscopy are discussed with relevance to the imaging of amyloid plaques that are pathognomonic of a variety of degenerative disorders. We present the results of linear birefringence, linear dichroism, and circular dichroism imaging of Congo red stained plaques ex vivo and in vitro. A new technique for measuring rapid changes in linear anisotropies is introduced. The application of polarimetric imaging as demonstrated here can be extended to broader pathological practice since polarimetric measurements are sensitive to transformations in tissues that are specific disease signatures.

Original languageEnglish (US)
Pages (from-to)324-338
Number of pages15
JournalMicron
Volume37
Issue number4
DOIs
StatePublished - Jun 2006

Fingerprint

Birefringence
Congo Red
Anisotropy
Amyloid Plaques
Circular Dichroism
Amyloid
dichroism
Microscopy
Dichroism
Imaging techniques
birefringence
signatures
disorders
microscopy
anisotropy
Optical microscopy
Tissue
In Vitro Techniques

Keywords

  • Alzheimer's disease
  • Amyloidosis
  • Circular dichroism
  • Circular extinction
  • Congo red
  • Linear birefringence
  • Linear dichroism

ASJC Scopus subject areas

  • Cell Biology
  • Materials Science(all)
  • Instrumentation
  • Biotechnology

Cite this

Kaminksy, W., Jin, L-W., Powell, S., Maezawa, I., Claborn, K., Branham, C., & Kahr, B. (2006). Polarimetric imaging of amyloid. Micron, 37(4), 324-338. https://doi.org/10.1016/j.micron.2005.10.014

Polarimetric imaging of amyloid. / Kaminksy, Werner; Jin, Lee-Way; Powell, Steven; Maezawa, Izumi; Claborn, Kacey; Branham, Charles; Kahr, Bart.

In: Micron, Vol. 37, No. 4, 06.2006, p. 324-338.

Research output: Contribution to journalArticle

Kaminksy, W, Jin, L-W, Powell, S, Maezawa, I, Claborn, K, Branham, C & Kahr, B 2006, 'Polarimetric imaging of amyloid', Micron, vol. 37, no. 4, pp. 324-338. https://doi.org/10.1016/j.micron.2005.10.014
Kaminksy W, Jin L-W, Powell S, Maezawa I, Claborn K, Branham C et al. Polarimetric imaging of amyloid. Micron. 2006 Jun;37(4):324-338. https://doi.org/10.1016/j.micron.2005.10.014
Kaminksy, Werner ; Jin, Lee-Way ; Powell, Steven ; Maezawa, Izumi ; Claborn, Kacey ; Branham, Charles ; Kahr, Bart. / Polarimetric imaging of amyloid. In: Micron. 2006 ; Vol. 37, No. 4. pp. 324-338.
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