Plk4/SAK/ZYG-1 in the regulation of centriole duplication

Chad G. Pearson, Mark Winey

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Centrioles organize both centrosomes and cilia. Centriole duplication is tightly regulated and coordinated with the cell cycle to limit duplication to only once per cell cycle. Defects in centriole number and structure are commonly found in cancer. Plk4/SAK and the functionally related Caenorhabditis elegans ZYG-1 kinases initiate centriole duplication. Several recent studies have elucidated the regulated activity of these kinases and potential downstream targets for centriole assembly.

Original languageEnglish (US)
Article number58
JournalF1000 Biology Reports
Issue number1
StatePublished - Nov 30 2010
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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