Abstract
Centrioles organize both centrosomes and cilia. Centriole duplication is tightly regulated and coordinated with the cell cycle to limit duplication to only once per cell cycle. Defects in centriole number and structure are commonly found in cancer. Plk4/SAK and the functionally related Caenorhabditis elegans ZYG-1 kinases initiate centriole duplication. Several recent studies have elucidated the regulated activity of these kinases and potential downstream targets for centriole assembly.
| Original language | English (US) |
|---|---|
| Article number | 58 |
| Journal | F1000 Biology Reports |
| Volume | 2 |
| Issue number | 1 |
| DOIs | |
| State | Published - Nov 30 2010 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
- Neuroscience(all)
- Pharmacology, Toxicology and Pharmaceutics(all)
Fingerprint Dive into the research topics of 'Plk4/SAK/ZYG-1 in the regulation of centriole duplication'. Together they form a unique fingerprint.
Cite this
Pearson, C. G., & Winey, M. (2010). Plk4/SAK/ZYG-1 in the regulation of centriole duplication. F1000 Biology Reports, 2(1), [58]. https://doi.org/10.3410/B2-58