Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections

Hwai-Jong Cheng, Anil Bagri, Avraham Yaron, Elke Stein, Samuel J. Pleasure, Marc Tessier-Lavigne

Research output: Contribution to journalArticlepeer-review

179 Scopus citations

Abstract

Plexins are receptors implicated in mediating signaling by semaphorins, a family of axonal chemorepellents. The role of specific plexins in mediating semaphorin function in vivo has not, however, yet been examined in vertebrates. Here, we show that plexin-A3 is the most ubiquitously expressed plexin family member within regions of the developing mammalian nervous system known to contain semaphorin-responsive neurons. Using a chimeric receptor construct, we provide evidence that plexin-A3 can transduce a repulsive signal in growth cones in vitro. Analysis of plexin-A3 knockout mice shows that plexin-A3 contributes to Sema3F and Sema3A signaling and that plexin-A3 regulates the development of hippocampal axonal projections in vivo.

Original languageEnglish (US)
Pages (from-to)249-263
Number of pages15
JournalNeuron
Volume32
Issue number2
DOIs
StatePublished - Oct 25 2001

ASJC Scopus subject areas

  • Neuroscience(all)

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