Platinum-sensitive recurrence in ovarian cancer: The role of tumor microenvironment

Jeremy Chien, Rui Kuang, Charles Landen, Viji Shridhar

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

Despite several advances in the understanding of ovarian cancer pathobiology, in terms of driver genetic alterations in high-grade serous cancer, histologic heterogeneity of epithelial ovarian cancer, cell-of-origin for ovarian cancer, the survival rate from ovarian cancer is disappointingly low when compared to that of breast or prostate cancer. One of the factors contributing to the poor survival rate from ovarian cancer is the development of chemotherapy resistance following several rounds of chemotherapy. Although unicellular drug resistance mechanisms contribute to chemotherapy resistance, tumor microenvironment and the extracellular matrix (ECM), in particular, is emerging as a significant determinant of a tumor's response to chemotherapy. In this review, we discuss the potential role of the tumor microenvironment in ovarian cancer recurrence and resistance to chemotherapy. Finally, we propose an alternative view of platinum-sensitive recurrence to describe a potential role of the ECM in the process.

Original languageEnglish (US)
Article numberArticle 251
JournalFrontiers in Oncology
Volume3 SEP
DOIs
StatePublished - Dec 31 2013
Externally publishedYes

Keywords

  • Cancer stem cell
  • Extracellular matrix
  • Ovarian cancer
  • Platinum resistance
  • Platinum-sensitive recurrence

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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