Platelet response to acute blood loss: An experimental study

Robert C. Lim, James W Holcroft, Donald D. Trunkey

Research output: Contribution to journalArticle

Abstract

The platelet changes associated with acute blood loss were studied in dogs and baboons. The circulating platelets decreased and aggregability increased in response to hemorrhage. Intrinsic ATP and ADP concentrations and ultrastructural morphology did not change significantly. These results explain, in part, the coagulopathy that occurs in the trauma victim in hemorrhagic shock. Based upon these observations, the authors describe a resuscitative program that includes whole blood and platelet administration.

Original languageEnglish (US)
Pages (from-to)524-527
Number of pages4
JournalJournal of the American College of Emergency Physicians
Volume4
Issue number6
DOIs
StatePublished - 1975
Externally publishedYes

Fingerprint

Blood Platelets
Hemorrhagic Shock
Papio
Adenosine Diphosphate
Adenosine Triphosphate
Dogs
Hemorrhage
Wounds and Injuries

Keywords

  • blood, clotting
  • blood, platelet
  • shock, hemorrhagic
  • shock, hypovolemic

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Platelet response to acute blood loss : An experimental study. / Lim, Robert C.; Holcroft, James W; Trunkey, Donald D.

In: Journal of the American College of Emergency Physicians, Vol. 4, No. 6, 1975, p. 524-527.

Research output: Contribution to journalArticle

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