Platelet reactivity in male smokers following the acute consumption of a flavanol-rich grapeseed extract

John A. Polagruto, Heidrun B. Gross, Faranak Kamangar, Ken Ichi Kosuna, Buxiang Sun, Hajime Fujii, Carl L Keen, Robert M. Hackman

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Epidemiological studies suggest that a high dietary intake of flavanols, a subclass of flavonoids, is associated with reduced risk of vascular disease. Clinical studies have also shown that the consumption of certain flavanol-rich foods (e.g., cocoa, tea, red wine), as well as intake of the individual flavanol (-)-epicatechin, can result in improvement in a number of parameters associated with vascular disease, including improved endothelial function, reduced platelet reactivity, and reduced oxidative stress. The present study assessed the effects of a flavanol-rich supplement on platelet reactivity and plasma oxidant defense in a group of smokers, a population at an elevated risk for vascular disease. Male smokers were randomly assigned to a placebo (n = 10) or a flavanol-rich grapeseed extract (FRGSE; n = 13) group, and after an overnight fast, blood samples were collected before and at 1, 2, and 6 hours following consumption of the placebo or supplement. The FRGSE supplement, but not the placebo, significantly decreased ADP-stimulated platelet reactivity at 1, 2, and 6 hours following intake (P < .05) compared to baseline levels. Similarly, the supplement, but not the placebo, decreased epinephrine-stimulated platelet reactivity 2 hours following consumption. Plasma antioxidant capacity (total radical trapping antioxidant potential), lipid oxidation (plasma thiobarbituric acid-reactive substances), and serum uric acid concentrations were not affected in either group. Thus smokers may obtain some health benefits from the consumption of certain flavanol-rich foods, beverages, and supplements.

Original languageEnglish (US)
Pages (from-to)725-730
Number of pages6
JournalJournal of Medicinal Food
Volume10
Issue number4
DOIs
StatePublished - Dec 1 2007

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grape seed extract
flavanols
Blood Platelets
Vascular Diseases
Placebos
vascular diseases
placebos
Antioxidants
Food and Beverages
Thiobarbituric Acid Reactive Substances
Catechin
Insurance Benefits
Tea
Wine
Dietary Supplements
Uric Acid
Flavonoids
Oxidants
tea (beverage)
Adenosine Diphosphate

Keywords

  • Cardiovascular disease
  • Dimers
  • Epicatechin
  • Flavanols
  • Platelet function
  • Procyanidin
  • Vascular function

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Polagruto, J. A., Gross, H. B., Kamangar, F., Kosuna, K. I., Sun, B., Fujii, H., ... Hackman, R. M. (2007). Platelet reactivity in male smokers following the acute consumption of a flavanol-rich grapeseed extract. Journal of Medicinal Food, 10(4), 725-730. https://doi.org/10.1089/jmf.2007.402

Platelet reactivity in male smokers following the acute consumption of a flavanol-rich grapeseed extract. / Polagruto, John A.; Gross, Heidrun B.; Kamangar, Faranak; Kosuna, Ken Ichi; Sun, Buxiang; Fujii, Hajime; Keen, Carl L; Hackman, Robert M.

In: Journal of Medicinal Food, Vol. 10, No. 4, 01.12.2007, p. 725-730.

Research output: Contribution to journalArticle

Polagruto, JA, Gross, HB, Kamangar, F, Kosuna, KI, Sun, B, Fujii, H, Keen, CL & Hackman, RM 2007, 'Platelet reactivity in male smokers following the acute consumption of a flavanol-rich grapeseed extract', Journal of Medicinal Food, vol. 10, no. 4, pp. 725-730. https://doi.org/10.1089/jmf.2007.402
Polagruto, John A. ; Gross, Heidrun B. ; Kamangar, Faranak ; Kosuna, Ken Ichi ; Sun, Buxiang ; Fujii, Hajime ; Keen, Carl L ; Hackman, Robert M. / Platelet reactivity in male smokers following the acute consumption of a flavanol-rich grapeseed extract. In: Journal of Medicinal Food. 2007 ; Vol. 10, No. 4. pp. 725-730.
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