Platelet activation in patients with sickle cell disease

Theodore Wun, Teresa Paglieroni, Arun Rangaswami, Patricia Hill Franklin, Jeanna L Welborn, Anthony Cheung, Fern Tablin

Research output: Contribution to journalArticle

101 Scopus citations

Abstract

Vascular occlusion and vasculopathy underlie much of the morbidity in patients with sickle cell anaemia. Platelets may play a role in this vasculopathy. Samples from 43 patients with sickle cell disease (SCD) were examined for evidence of platelet activation using fluorescent-labelled monoclonal antibodies and flow cytometry. There was increased expression of activation-dependent antigens on the platelets from patients with SCD compared to those from both Caucasian and African-American controls. In addition, SCD patients had increased levels of platelet microparticles. Platelets are activated in patients with sickle cell disease. The contribution of platelet activation to sickle cell pathophysiology is under active investigation in our laboratories.

Original languageEnglish (US)
Pages (from-to)741-749
Number of pages9
JournalBritish Journal of Haematology
Volume100
Issue number4
DOIs
StatePublished - 1998

Keywords

  • Microparticle
  • Platelet activation
  • Sickle cell
  • Vascular disease

ASJC Scopus subject areas

  • Hematology

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