Platelet activation and platelet-erythrocyte aggregates in patients with sickle cell anemia

Ted Wun, Teresa Paglieroni, Fern Tablin, Jeanna Welborn, Karen Nelson, Anthony Cheung

Research output: Contribution to journalArticle

114 Scopus citations

Abstract

Vascular occlusion and vasculopathy underlie much of the morbidity in patients with sickle cell anemia. Platelets may play a role in this vasculopathy. Samples from 12 adult patients with sickle cell anemia were examined for evidence of platelet activation and formation of platelet-erythrocyte aggregates (PEA) using fluorescent-labeled monoclonal antibodies and flow cytometry. We noted an increased expression of activation-dependent antigens on the platelets from patients with sickle cell anemia compared with those from both white and black control subjects. In addition, patients with sickle cell anemia had increased levels of platelet microparticles and PEA. Platelets are activated in patients with sickle cell anemia and they adhere to sickle erythrocytes. The significance of this activation and adherence are the subject of further investigation.

Original languageEnglish (US)
Pages (from-to)507-516
Number of pages10
JournalJournal of Laboratory and Clinical Medicine
Volume129
Issue number5
StatePublished - May 1997

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

Cite this