Plasmodium falciparum infection rates for some Anopheles spp. from Guinea-Bissau, West Africa

Yoosook Lee, Michelle R. Sanford, Anthony J. Cornel, Catelyn C. Nieman, Joao Dinis, Clare D. Marsden, Allison M. Weakley, Sarah Han, Amabelia Rodrigues, Gregory C Lanzaro

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6 Scopus citations

Abstract

Presence of Plasmodium falciparum circumsporozoite protein (CSP) was detected by enzyme linked immunosorbent assay (ELISA) in a sample of Anopheles gambiae s.s., A. melas and A. pharoensis collected in Guinea-Bissau during October and November 2009. The percentage of P. falciparum infected samples (10.2% overall; confidence interval (CI): 7.45-13.6%) was comparable to earlier studies from other sites in Guinea-Bissau (9.6-12.4%). The majority of the specimens collected were identified as A. gambiae which had an individual infection rate of 12.6 % (CI: 8.88-17.6) across collection sites. A small number of specimens of A. coluzzii, A. coluzzii x A. gambiae hybrids, A. melas and A. pharoensis were collected and had infection rates of 4.3% (CI:0.98-12.4), 4.1% (CI:0.35-14.5), 11.1% (CI:1.86-34.1) and 33.3% (CI:9.25-70.4) respectively. Despite being present in low numbers in indoor collections, the exophilic feeding behaviors of A. melas (N=18) and A. pharoensis (N=6) and high infection rates observed in this survey suggest falciparum-malaria transmission potential outside of the protection of bed nets.

Original languageEnglish (US)
JournalF1000Research
Volume3
DOIs
StatePublished - Nov 5 2014

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Lee, Y., Sanford, M. R., Cornel, A. J., Nieman, C. C., Dinis, J., Marsden, C. D., Weakley, A. M., Han, S., Rodrigues, A., & Lanzaro, G. C. (2014). Plasmodium falciparum infection rates for some Anopheles spp. from Guinea-Bissau, West Africa. F1000Research, 3. https://doi.org/10.12688/f1000research.5485.2