This study reports on the measurement of potassium thiocyanate-extractable plasminogen activator in human uterine tissue. Specifically, the activator content of the endometrial functionalis and subjacent myometrium were separately analyzed. No significant variation in this fibrinolytic activator among various geographical locations within the uterus (cornua, fundus, corpus, isthmus) were found. Superficial myometrium demonstrated consistently higher amounts of activator than the endometrial functionalis, but myometrial and endometrial values paralleled one another throughout the intermenstrual ovarian cycle. Highest levels of activator occurred in the late follicular phase and were next highest prior to menses. The apparent lack of correlation with vascularity in the endometrial functionalis suggests that extractable activator is not equivalent to the vascular plasminogen activator detected by the histochemical fibrin slide technique.
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