Plasmacytoid dendritic cells of different origins have distinct characteristics and function

Studies of lymphoid progenitors versus myeloid progenitors

Guo Xiang Yang, Zhe Xiong Lian, Kentaro Kikuchi, Yuki Moritoki, Aftab A. Ansari, Yong Jun Liu, Susumu Ikehara, M. Eric Gershwin

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Abstract

Plasmacytoid dendritic cells (pDCs) play a central role in host innate and adaptive immunity and are thought to be of lymphoid origin. However, in IL-7Rα-/- mice, which are deficient in T and B lymphocytes, pDCs are still found in lymphoid organs, which suggests that there is a lymphoid-independent pathway for the development of pDCs. Previous work has demonstrated that pDCs originate from both lymphoid and myeloid progenitors (MPs). However, it is not clear whether the function of pDCs is different relative to their origin. In an effort to compare the characteristics and functions between pDCs generated from different progenitors, we performed adoptive transfer studies using highly enriched populations of common lymphoid progenitors (CLPs) and MPs from the bone marrow of control mice and examined their potential and developmental kinetics for the generation of pDCs. Interestingly, although CLPs were polarized to generate pDCs, MPs were polarized to generate conventional dendritic cells and the kinetics of pDC generation from MPs was reached earlier than from CLPs. Furthermore, CLPs have the potential to generate more pDCs on a per cell basis. Moreover, MP-derived pDCs produce relatively higher levels of IFN-α than CLP-derived pDCs following CpG stimulation. These data indicate that MPs are multipotential and have the capacity to develop into not only myeloid cells, but also pDCs, which have distinct characteristics and function compared to that of lymphoid origin and, therefore, imply a more important role for MP-derived pDCs in conditions where the function of lymphoid progenitors is impaired or compromised.

Original languageEnglish (US)
Pages (from-to)7281-7287
Number of pages7
JournalJournal of Immunology
Volume175
Issue number11
StatePublished - Dec 1 2005

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Dendritic Cells
Lymphoid Progenitor Cells
Adoptive Transfer
Adaptive Immunity
Myeloid Cells
Innate Immunity
B-Lymphocytes
Bone Marrow
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology

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Plasmacytoid dendritic cells of different origins have distinct characteristics and function : Studies of lymphoid progenitors versus myeloid progenitors. / Yang, Guo Xiang; Lian, Zhe Xiong; Kikuchi, Kentaro; Moritoki, Yuki; Ansari, Aftab A.; Liu, Yong Jun; Ikehara, Susumu; Gershwin, M. Eric.

In: Journal of Immunology, Vol. 175, No. 11, 01.12.2005, p. 7281-7287.

Research output: Contribution to journalArticle

Yang, Guo Xiang ; Lian, Zhe Xiong ; Kikuchi, Kentaro ; Moritoki, Yuki ; Ansari, Aftab A. ; Liu, Yong Jun ; Ikehara, Susumu ; Gershwin, M. Eric. / Plasmacytoid dendritic cells of different origins have distinct characteristics and function : Studies of lymphoid progenitors versus myeloid progenitors. In: Journal of Immunology. 2005 ; Vol. 175, No. 11. pp. 7281-7287.
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