Plasma total-tau as a biomarker of stroke risk in the community

Matthew P. Pase, Jayandra J. Himali, Hugo J. Aparicio, Jose Rafael Romero, Claudia L. Satizabal, Pauline Maillard, Charles DeCarli, Alexa S. Beiser, Sudha Seshadri

Research output: Contribution to journalArticle

Abstract

Higher plasma total-tau level is associated with incident dementia, but its relationship with stroke risk is unknown. In this prospective community-based study, we evaluated plasma total-tau level as a biomarker of stroke risk in 2,794 Framingham Heart Study participants. Persons with plasma total-tau levels in the top quintile, versus the bottom 4, had an increased risk of incident stroke over a mean follow-up of 8.3 years (hazard ratio = 2.01; 95% confidence interval = 1.32–3.08) following adjustments for age, sex, and stroke risk factors. Our findings demonstrate that plasma total-tau relates to the risk of stroke in a community sample. ANN NEUROL 2019;86:463–467.

Original languageEnglish (US)
Pages (from-to)463-467
Number of pages5
JournalAnnals of Neurology
Volume86
Issue number3
DOIs
StatePublished - Jan 1 2019

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Biomarkers
Stroke
Dementia
Confidence Intervals

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Pase, M. P., Himali, J. J., Aparicio, H. J., Romero, J. R., Satizabal, C. L., Maillard, P., ... Seshadri, S. (2019). Plasma total-tau as a biomarker of stroke risk in the community. Annals of Neurology, 86(3), 463-467. https://doi.org/10.1002/ana.25542

Plasma total-tau as a biomarker of stroke risk in the community. / Pase, Matthew P.; Himali, Jayandra J.; Aparicio, Hugo J.; Romero, Jose Rafael; Satizabal, Claudia L.; Maillard, Pauline; DeCarli, Charles; Beiser, Alexa S.; Seshadri, Sudha.

In: Annals of Neurology, Vol. 86, No. 3, 01.01.2019, p. 463-467.

Research output: Contribution to journalArticle

Pase, MP, Himali, JJ, Aparicio, HJ, Romero, JR, Satizabal, CL, Maillard, P, DeCarli, C, Beiser, AS & Seshadri, S 2019, 'Plasma total-tau as a biomarker of stroke risk in the community', Annals of Neurology, vol. 86, no. 3, pp. 463-467. https://doi.org/10.1002/ana.25542
Pase MP, Himali JJ, Aparicio HJ, Romero JR, Satizabal CL, Maillard P et al. Plasma total-tau as a biomarker of stroke risk in the community. Annals of Neurology. 2019 Jan 1;86(3):463-467. https://doi.org/10.1002/ana.25542
Pase, Matthew P. ; Himali, Jayandra J. ; Aparicio, Hugo J. ; Romero, Jose Rafael ; Satizabal, Claudia L. ; Maillard, Pauline ; DeCarli, Charles ; Beiser, Alexa S. ; Seshadri, Sudha. / Plasma total-tau as a biomarker of stroke risk in the community. In: Annals of Neurology. 2019 ; Vol. 86, No. 3. pp. 463-467.
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