Abstract
Introduction: The Framingham risk score predicts a patient's 10-year risk of developing cardiovascular disease. Many risk factors included in its calculation influence or are influenced by circulating testosterone. To investigate the possible association between testosterone and cardiovascular risk, as defined by the Framingham score, a Veterans Affairs (VA) database was analyzed. Methods: A retrospective chart review was performed. Inclusion criteria were male sex and age ≥ 20 years. Exclusion criteria included pre-existing cardiovascular disease, stroke, and diabetes. Data were collected on veterans who had total plasma testosterone checked in the year 2008. Results: The study included 1,479 patients (mean age 61 years). Framingham score was negatively associated with both total testosterone (p<0.0001) and free testosterone (p=0.0003). There was a positive association between total testosterone and high-density lipoprotein and negative associations between total testosterone and body mass index (BMI), total cholesterol, triglycerides, and blood pressure medication use. Free testosterone was positively associated with total cholesterol, low-density lipoprotein, and current smoking status and negatively associated with age, BMI, and blood pressure medication use. The BMI was not associated with Framingham score. Conclusions: Lower plasma testosterone may suggest the presence of cardiovascular risk factors and potentially increased risk for heart disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 134-139 |
| Number of pages | 6 |
| Journal | Aging Male |
| Volume | 15 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 2012 |
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Keywords
- Cardiovascular risk
- Framingham score
- Hypogonadism
- Testosterone deficiency
ASJC Scopus subject areas
- Geriatrics and Gerontology
Cite this
Plasma testosterone is associated with Framingham risk score. / Chock, Brandon; Lin, Tzu Chun; Li, Chin-Shang; Swislocki, Arthur L.
In: Aging Male, Vol. 15, No. 3, 09.2012, p. 134-139.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Plasma testosterone is associated with Framingham risk score
AU - Chock, Brandon
AU - Lin, Tzu Chun
AU - Li, Chin-Shang
AU - Swislocki, Arthur L
PY - 2012/9
Y1 - 2012/9
N2 - Introduction: The Framingham risk score predicts a patient's 10-year risk of developing cardiovascular disease. Many risk factors included in its calculation influence or are influenced by circulating testosterone. To investigate the possible association between testosterone and cardiovascular risk, as defined by the Framingham score, a Veterans Affairs (VA) database was analyzed. Methods: A retrospective chart review was performed. Inclusion criteria were male sex and age ≥ 20 years. Exclusion criteria included pre-existing cardiovascular disease, stroke, and diabetes. Data were collected on veterans who had total plasma testosterone checked in the year 2008. Results: The study included 1,479 patients (mean age 61 years). Framingham score was negatively associated with both total testosterone (p<0.0001) and free testosterone (p=0.0003). There was a positive association between total testosterone and high-density lipoprotein and negative associations between total testosterone and body mass index (BMI), total cholesterol, triglycerides, and blood pressure medication use. Free testosterone was positively associated with total cholesterol, low-density lipoprotein, and current smoking status and negatively associated with age, BMI, and blood pressure medication use. The BMI was not associated with Framingham score. Conclusions: Lower plasma testosterone may suggest the presence of cardiovascular risk factors and potentially increased risk for heart disease.
AB - Introduction: The Framingham risk score predicts a patient's 10-year risk of developing cardiovascular disease. Many risk factors included in its calculation influence or are influenced by circulating testosterone. To investigate the possible association between testosterone and cardiovascular risk, as defined by the Framingham score, a Veterans Affairs (VA) database was analyzed. Methods: A retrospective chart review was performed. Inclusion criteria were male sex and age ≥ 20 years. Exclusion criteria included pre-existing cardiovascular disease, stroke, and diabetes. Data were collected on veterans who had total plasma testosterone checked in the year 2008. Results: The study included 1,479 patients (mean age 61 years). Framingham score was negatively associated with both total testosterone (p<0.0001) and free testosterone (p=0.0003). There was a positive association between total testosterone and high-density lipoprotein and negative associations between total testosterone and body mass index (BMI), total cholesterol, triglycerides, and blood pressure medication use. Free testosterone was positively associated with total cholesterol, low-density lipoprotein, and current smoking status and negatively associated with age, BMI, and blood pressure medication use. The BMI was not associated with Framingham score. Conclusions: Lower plasma testosterone may suggest the presence of cardiovascular risk factors and potentially increased risk for heart disease.
KW - Cardiovascular risk
KW - Framingham score
KW - Hypogonadism
KW - Testosterone deficiency
UR - http://www.scopus.com/inward/record.url?scp=84864862923&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864862923&partnerID=8YFLogxK
U2 - 10.3109/13685538.2011.654369
DO - 10.3109/13685538.2011.654369
M3 - Article
C2 - 22364636
AN - SCOPUS:84864862923
VL - 15
SP - 134
EP - 139
JO - Aging Male
JF - Aging Male
SN - 1368-5538
IS - 3
ER -