Plasma taurine concentrations in normal dogs and in dogs with heart disease.

G. A. Kramer, Mark D Kittleson, P. R. Fox, J. Lewis, P. D. Pion

Research output: Contribution to journalArticle

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Abstract

Plasma taurine concentrations were determined in 76 dogs with dilated cardiomyopathy (DCM), 28 dogs with acquired valvular disease (AVD), and 47 normal (control) dogs. The data were collected at 2 referral centers, The Animal Medical Center, New York, NY (AMC), and the University of California, Davis (UCD), and the studies were conducted independently. Different anticoagulants (sodium citrate at AMC and lithium heparin at UCD) were used to collect the plasma samples. Paired analysis of samples showed a significant difference in plasma taurine concentrations, depending on the anticoagulant used. Consequently, results from each clinic were analyzed separately. Plasma taurine concentrations were significantly higher in dogs with AVD (median, 133 nmol/mL; range, 25 to 229 nmol/mL) than in control dogs (median, 63 nmol/mL; range 44 to 224 nmol/mL) and dogs with DCM (median, 72 nmol/mL; range, 1 to 247 nmol/mL) at AMC (P < .001). The number of dogs with AVD at UCD was too small to draw meaningful conclusions. At UCD, the median plasma taurine concentration was 98 nmol/mL (range, 28-169 nmol/mL) in dogs with AVD, 75 nmol/mL (range, 0.1-184 nmol/mL) in dogs with DCM, and 88 nmol/mL (range 52-180 nmol/mL) in control dogs. There were no significant differences in plasma taurine concentrations between dogs with DCM and the control dogs at either hospital. Congestive heart failure and administration of cardiac medication had no significant effect on plasma taurine concentrations. Plasma taurine concentration was low (< 25 nmol/mL) in 17% (13/76) of the dogs with DCM. Seven of the 13 dogs with low plasma taurine concentrations were Cocker Spaniels or Golden Retrievers.(ABSTRACT TRUNCATED AT 250 WORDS)

Original languageEnglish (US)
Pages (from-to)253-258
Number of pages6
JournalJournal of veterinary internal medicine / American College of Veterinary Internal Medicine
Volume9
Issue number4
StatePublished - Jul 1995

Fingerprint

Taurine
taurine
heart diseases
Heart Diseases
Dogs
dogs
cardiomyopathy
Dilated Cardiomyopathy
anticoagulants
Anticoagulants
Cocker Spaniel
sodium citrate
Golden Retriever
lithium
heparin
heart failure
Lithium
drug therapy
Heparin

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Plasma taurine concentrations in normal dogs and in dogs with heart disease. / Kramer, G. A.; Kittleson, Mark D; Fox, P. R.; Lewis, J.; Pion, P. D.

In: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, Vol. 9, No. 4, 07.1995, p. 253-258.

Research output: Contribution to journalArticle

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