Plasma renin activity in children with coarctation of the aorta

Ezra A Amsterdam, William H. Albers, A. Richard Christlieb, Clarence L. Morgan, Alexander S. Nadas, Roger B. Hickler

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21 Scopus citations


Peripheral plasma renin activity was studied in 16 children, aged 2 to 13 years, with coarctation of the aorta and in 11 normal children. There was no significant difference in plasma renin activity between the two groups. Seven of the patients with coarctation of the aorta had angiotensin infusion tests, all of which were negative. In a group of patients with renovascular hypertension, a significant proportion had elevated peripheral plasma renin activity. These findings suggest that the hypertension associated with coarctation of the aorta is not associated with increased activity of the reninangiotensin system. The hypertension may, however, be renal in origin without operating through the reninangiotensin system. It is also possible that kidney renin secretion may be elevated to a degree that could lead to hypertension but not produce a detectable increase in peripheral plasma renin activity.

Original languageEnglish (US)
Pages (from-to)396-399
Number of pages4
JournalThe American journal of cardiology
Issue number3
StatePublished - Mar 1969
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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