Plasma oxidizability in Mexican-Americans and non-Hispanic whites

Steven M. Haffner, Heikki Miettinen, Michael P. Stern, Ahmad Agil, Ishwarlal Jialal

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Several lines of evidence support an atherogenic role for oxidized low- density lipoprotein (LDL). Previous studies have suggested that although Mexican-Americans have an increased rate of diabetes, obesity, elevated triglyceride levels, and low high-density lipoprotein (HDL) cholesterol levels, their rates of coronary heart disease (CHD) are similar or possibly lower than in non-Hispanic whites, Mexican-Americans have smaller, denser LOL than non-Hispanic whites. On the basis of this latter observation, we postulated that lipid peroxide (LPO) levels would be increased in Mexican- Americans. We examined the oxidizability of plasma in 50 Mexican-Americans and 50 non-Hispanic whites from the San Antonio Heart Study, e population- based study of diabetes and cardiovascular disease, at baseline and after coincubation with a metal-independent system (2'2'-azobis-2-amidinopropane hydrochloride [AAPH]) and a metal-dependent system (Fe2+/H2O2) of oxidation. LPO levels were measured by a modified fluorimetric assay. Vitamin E and plasma fatty acid composition were also determined. We found significantly higher LPO levels at baseline and after AAPH coincubation in Mexican-Americans than in non-Hispanic whites (baseline, 2.75 ± .09 v 2.07 ± .09 μmol/L, P < .001; post-AAPH, 5.49 ± .14 v 5.07 ± .04 μmol/L, P = .037). However, no significant ethnic differences were seen after coincubation with Fe2+/H2O2. Diabetes and cigarette-smoking were also associated with higher LPO levels. Mexican-Americans also had lower levels of vitamin E (the predominant lipid-soluble antioxidant in plasma) than non- Hispanic whites, although these differences only partially explained the differences in susceptibility to oxidation. Plasma fatty acids were similar in Mexican-Americans and non-Hispanic whites, suggesting only small differences in diet composition. We conclude that LPO levels are higher in Mexican-Americans than in non-Hispanic whites, and that these results are only partially related to differences in vitamin E levels.

Original languageEnglish (US)
Pages (from-to)876-881
Number of pages6
JournalMetabolism: Clinical and Experimental
Volume45
Issue number7
DOIs
StatePublished - 1996
Externally publishedYes

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Lipid Peroxides
Vitamin E
Fatty Acids
Metals
Hispanic Americans
LDL Cholesterol
HDL Cholesterol
Coronary Disease
Triglycerides
Cardiovascular Diseases
Obesity
Antioxidants
Smoking
Observation
Diet
Lipids
Population

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Plasma oxidizability in Mexican-Americans and non-Hispanic whites. / Haffner, Steven M.; Miettinen, Heikki; Stern, Michael P.; Agil, Ahmad; Jialal, Ishwarlal.

In: Metabolism: Clinical and Experimental, Vol. 45, No. 7, 1996, p. 876-881.

Research output: Contribution to journalArticle

Haffner, SM, Miettinen, H, Stern, MP, Agil, A & Jialal, I 1996, 'Plasma oxidizability in Mexican-Americans and non-Hispanic whites', Metabolism: Clinical and Experimental, vol. 45, no. 7, pp. 876-881. https://doi.org/10.1016/S0026-0495(96)90163-8
Haffner, Steven M. ; Miettinen, Heikki ; Stern, Michael P. ; Agil, Ahmad ; Jialal, Ishwarlal. / Plasma oxidizability in Mexican-Americans and non-Hispanic whites. In: Metabolism: Clinical and Experimental. 1996 ; Vol. 45, No. 7. pp. 876-881.
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