Plasma omega 3 polyunsaturated fatty acid status and monounsaturated fatty acids are altered by chronic social stress and predict endocrine responses to acute stress in titi monkeys

K. D. Laugero, J. T. Smilowitz, J. B. German, M. R. Jarcho, S. P. Mendoza, K. L. Bales

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Disturbances in fatty acid (FA) metabolism may link chronic psychological stress, endocrine responsiveness, and psychopathology. Therefore, lipid metabolome-wide responses and their relationships with endocrine (cortisol, insulin, and adiponectin) responsiveness to acute stress (AS) were assessed in a primate model of chronic social stress (CS). Compared to controls (not exposed to CS), CS increased (P≤0.05) circulating triacylglycerol (TG) and phosphatidylethanolamine (PE) n-6/n-3 and reduced (P≤0.05) cholesterol ester (CE) 16:1n7 and phosphatidylcholine (PC) 18:1n7, suggesting lower omega-3 FA status and stearoyl-CoA desaturase activity, respectively. Cortisol responses to AS positively correlated with TG n-6/n-3 (r=0.93; P=0.007), but only in CS monkeys. The adiponectin response to AS inversely correlated with CE n-6/n3 (r=-0.89; P=0.045) and positively with TG 16:1n7 (r=0.98; P=0.004), only in CS monkeys. Our results are consistent with previously reported FA profiles in stress-related psychopathology and suggest that compositional changes of specific lipid FAs may form new functional markers of chronic psychological stress.

Original languageEnglish (US)
Pages (from-to)71-78
Number of pages8
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume84
Issue number3-4
DOIs
StatePublished - Mar 2011

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Monounsaturated Fatty Acids
Omega-3 Fatty Acids
Unsaturated Fatty Acids
Haplorhini
Triglycerides
Cholesterol Esters
Adiponectin
Psychopathology
Plasmas
Psychological Stress
Hydrocortisone
Fatty Acids
Stearoyl-CoA Desaturase
Lipids
Metabolome
Phosphatidylcholines
Primates
Insulin
Metabolism

Keywords

  • Adiponectin metabolomics
  • Chronic stress
  • Cortisol
  • Fatty acid metabolism
  • Insulin
  • Monkey

ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry

Cite this

Plasma omega 3 polyunsaturated fatty acid status and monounsaturated fatty acids are altered by chronic social stress and predict endocrine responses to acute stress in titi monkeys. / Laugero, K. D.; Smilowitz, J. T.; German, J. B.; Jarcho, M. R.; Mendoza, S. P.; Bales, K. L.

In: Prostaglandins Leukotrienes and Essential Fatty Acids, Vol. 84, No. 3-4, 03.2011, p. 71-78.

Research output: Contribution to journalArticle

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