Plasma membrane involvement in brown fat thermogenesis.

Barbara A Horwitz

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Recent experiments indicate that plasma membranes of brown adipocytes contain distinct alpha- and beta-adrenergic receptors able to recognize norepinephrine. Although activation of either receptor leads to brown fat thermogenesis via pathways that have some, but not all, events in common, the beta-induced calorigenesis appears quantitatively greater than that elicited by the alpha-pathway. The sensitivity of the adrenergic-evoked respiration to Na+/K+ pump blockade as well as to atractyloside supports the view that a significant portion of brown fat thermogenesis reflects increased ATP turnover and enhanced mitochondrial ATP synthesis.

Original languageEnglish (US)
Pages (from-to)19-23
Number of pages5
JournalExperientia. Supplementum
Volume32
StatePublished - 1978
Externally publishedYes

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Brown Adipose Tissue
Thermogenesis
Atractyloside
Adenosine Triphosphate
Cell Membrane
Brown Adipocytes
Mitochondrial Turnover
Receptors, Adrenergic, alpha
Receptors, Adrenergic, beta
Adrenergic Agents
Norepinephrine
Respiration

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Plasma membrane involvement in brown fat thermogenesis. / Horwitz, Barbara A.

In: Experientia. Supplementum, Vol. 32, 1978, p. 19-23.

Research output: Contribution to journalArticle

Horwitz, Barbara A. / Plasma membrane involvement in brown fat thermogenesis. In: Experientia. Supplementum. 1978 ; Vol. 32. pp. 19-23.
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