Abstract
Recent experiments indicate that plasma membranes of brown adipocytes contain distinct alpha- and beta-adrenergic receptors able to recognize norepinephrine. Although activation of either receptor leads to brown fat thermogenesis via pathways that have some, but not all, events in common, the beta-induced calorigenesis appears quantitatively greater than that elicited by the alpha-pathway. The sensitivity of the adrenergic-evoked respiration to Na+/K+ pump blockade as well as to atractyloside supports the view that a significant portion of brown fat thermogenesis reflects increased ATP turnover and enhanced mitochondrial ATP synthesis.
Original language | English (US) |
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Pages (from-to) | 19-23 |
Number of pages | 5 |
Journal | Experientia. Supplementum |
Volume | 32 |
State | Published - 1978 |
Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)