Plasma membrane involvement in brown fat thermogenesis.

Barbara A Horwitz

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Recent experiments indicate that plasma membranes of brown adipocytes contain distinct alpha- and beta-adrenergic receptors able to recognize norepinephrine. Although activation of either receptor leads to brown fat thermogenesis via pathways that have some, but not all, events in common, the beta-induced calorigenesis appears quantitatively greater than that elicited by the alpha-pathway. The sensitivity of the adrenergic-evoked respiration to Na+/K+ pump blockade as well as to atractyloside supports the view that a significant portion of brown fat thermogenesis reflects increased ATP turnover and enhanced mitochondrial ATP synthesis.

Original languageEnglish (US)
Pages (from-to)19-23
Number of pages5
JournalExperientia. Supplementum
Volume32
StatePublished - 1978
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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