Abstract
Recent experiments indicate that plasma membranes of brown adipocytes contain distinct alpha- and beta-adrenergic receptors able to recognize norepinephrine. Although activation of either receptor leads to brown fat thermogenesis via pathways that have some, but not all, events in common, the beta-induced calorigenesis appears quantitatively greater than that elicited by the alpha-pathway. The sensitivity of the adrenergic-evoked respiration to Na+/K+ pump blockade as well as to atractyloside supports the view that a significant portion of brown fat thermogenesis reflects increased ATP turnover and enhanced mitochondrial ATP synthesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 19-23 |
| Number of pages | 5 |
| Journal | Experientia. Supplementum |
| Volume | 32 |
| State | Published - 1978 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Plasma membrane involvement in brown fat thermogenesis. / Horwitz, Barbara A.
In: Experientia. Supplementum, Vol. 32, 1978, p. 19-23.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Plasma membrane involvement in brown fat thermogenesis.
AU - Horwitz, Barbara A
PY - 1978
Y1 - 1978
N2 - Recent experiments indicate that plasma membranes of brown adipocytes contain distinct alpha- and beta-adrenergic receptors able to recognize norepinephrine. Although activation of either receptor leads to brown fat thermogenesis via pathways that have some, but not all, events in common, the beta-induced calorigenesis appears quantitatively greater than that elicited by the alpha-pathway. The sensitivity of the adrenergic-evoked respiration to Na+/K+ pump blockade as well as to atractyloside supports the view that a significant portion of brown fat thermogenesis reflects increased ATP turnover and enhanced mitochondrial ATP synthesis.
AB - Recent experiments indicate that plasma membranes of brown adipocytes contain distinct alpha- and beta-adrenergic receptors able to recognize norepinephrine. Although activation of either receptor leads to brown fat thermogenesis via pathways that have some, but not all, events in common, the beta-induced calorigenesis appears quantitatively greater than that elicited by the alpha-pathway. The sensitivity of the adrenergic-evoked respiration to Na+/K+ pump blockade as well as to atractyloside supports the view that a significant portion of brown fat thermogenesis reflects increased ATP turnover and enhanced mitochondrial ATP synthesis.
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UR - http://www.scopus.com/inward/citedby.url?scp=0017909603&partnerID=8YFLogxK
M3 - Article
C2 - 206457
AN - SCOPUS:0017909603
VL - 32
SP - 19
EP - 23
JO - Experientia. Supplementum
JF - Experientia. Supplementum
SN - 1023-294X
ER -