Plasma levels of myeloperoxidase are not elevated in patients with stable coronary artery disease

Lukas Kubala, Guijing Lu, Stephan Baldus, Lars Berglund, Jason P. Eiserich

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Background: Plasma and serum levels of myeloperoxidase (MPO), a redox-active hemoprotein released by polymorphonuclear neutrophils (PMN) upon activation, is now recognized as a powerful prognostic determinant of myocardial infarction in patients suffering acute coronary syndromes. However, there is limited information on whether systemic MPO levels are also elevated and of discriminating value in patients with stable coronary artery disease (CAD) representing different ethnic groups. Methods: Plasma levels of MPO and traditional CAD risk factors were quantified in African American and Caucasian patients (n = 557) undergoing elective coronary angiography. Results: MPO levels did not differ significantly between patients with or without CAD [421 pM (321, 533) vs. 412 pM (326, 500), p > 0.05]. MPO levels were similar across ethnicity and gender, and correlated positively with CRP and fibrinogen levels (r = 0.132, p = 0.002 and r = 0.106, p = 0.011, respectively). Conclusion: In conclusion, plasma MPO levels were not elevated in patients with stable CAD, suggesting that systemic release of MPO is not a characteristic feature of asymptomatic CAD.

Original languageEnglish (US)
Pages (from-to)59-62
Number of pages4
JournalClinica Chimica Acta
Volume394
Issue number1-2
DOIs
StatePublished - Aug 2008

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Peroxidase
Coronary Artery Disease
Plasmas
Neutrophil Activation
Angiography
Acute Coronary Syndrome
Coronary Angiography
Ethnic Groups
African Americans
Fibrinogen
Oxidation-Reduction
Chemical activation
Myocardial Infarction
Serum

Keywords

  • Cardiovascular diseases
  • Myeloperoxidase
  • Polymorphonuclear neutrophils
  • Risk factors

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry

Cite this

Plasma levels of myeloperoxidase are not elevated in patients with stable coronary artery disease. / Kubala, Lukas; Lu, Guijing; Baldus, Stephan; Berglund, Lars; Eiserich, Jason P.

In: Clinica Chimica Acta, Vol. 394, No. 1-2, 08.2008, p. 59-62.

Research output: Contribution to journalArticle

Kubala, Lukas ; Lu, Guijing ; Baldus, Stephan ; Berglund, Lars ; Eiserich, Jason P. / Plasma levels of myeloperoxidase are not elevated in patients with stable coronary artery disease. In: Clinica Chimica Acta. 2008 ; Vol. 394, No. 1-2. pp. 59-62.
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