Plasma glutathione concentrations in children infected with human immunodeficiency virus

Jose F. Rodriguez, Joel Cordero, Caroline J Chantry, Shirley González, Carmen Rivera, Irma Febo, Angel Colón, Clemente Díaz

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Background. Glutathione (GSH) is the principal intracellular defense against oxidants, and HIV-infected individuals tend to have subnormal concentrations in plasma. This GSH deficiency may contribute to the pathogenesis of disease progression. In the pediatric population correlations between GSH concentrations with clinical, immunologic and virologic disease profiles are scarce. Objectives. The main objectives of this study were (1) to compare plasma GSH concentrations of HIV-infected children and healthy controls and (2) to correlate GSH values with clinical, immunologic and virologic disease indices. Methods. Twenty-four HIV-infected and 24 healthy control children entered the study. Plasma concentrations of total glutathione and related thiols were determined. Results. The difference in mean plasma GSH concentrations between HIV-infected (2.96 ± 0.31 μM) and control (6.62 ± 0.58 μM) groups was highly significant (P < 0.0001). Linear regression analyses in HIV-infected patients revealed significant correlations between GSH and both absolute CD4+ cell counts (r = 0.56, P = 0.004) and viral load measured as log HIV-RNA PCR (r = -0.49, P = 0.018). GSH concentrations did not significantly correlate with CDC clinical stage but were lower in HIV-infected patients with growth failure (1.60 ± 0.54 μM vs. non-growth failure (3.23 ± 0.33 μM); P = 0.05. Conclusions. This study confirmed that HIVinfected children are deficient in plasma GSH concentrations compared with healthy controls. We documented that low GSH concentrations in HIV-infected children are directly correlated with CD4+ cell counts and inversely correlated with vital loads. These findings support a possible role of GSH in the pathogenesis of HIV disease progression.

Original languageEnglish (US)
Pages (from-to)236-241
Number of pages6
JournalPediatric Infectious Disease Journal
Volume17
Issue number3
DOIs
StatePublished - Mar 1998
Externally publishedYes

Keywords

  • Children
  • Glutathione
  • Human immunodeficiency virus
  • Vital loads

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)

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