Abstract
Epidemiological and clinical research studies have provided ample evidence demonstrating that consumption of sugar-sweetened beverages increases risk factors involved in the development of obesity, Type 2 diabetes, and cardiovascular disease (CVD). Our previous study demonstrated that when compared with aspartame (Asp), 2 wk of high-fructose corn syrup (HFCS)-sweetened beverages provided at 25% of daily energy requirement was associated with increased body weight, postprandial (pp) triglycerides (TG), and fasting and pp CVD risk factors in young adults. The fatty acid ethanolamide, anandamide (AEA), and the monoacylglycerol, 2-arachidonoyl-sn-glycerol (2-AG), are two primary endocannabinoids (ECs) that play a role in regulating food intake, increasing adipose storage, and regulating lipid metabolism. Therefore, we measured plasma concentrations of ECs and their analogs, oleoylethanolamide (OEA), docosahexaenoyl ethanolamide (DHEA), and docosahexaenoyl glycerol (DHG), in participants from our previous study who consumed HFCS-or Asp-sweetened beverages to determine associations with weight gain and CVD risk factors. Two-week exposure to either HFCS-or Asp-sweetened beverages resulted in significant differences in the changes in fasting levels of OEA and DHEA between groups after the testing period. Subjects who consumed Asp, but not HFCS, displayed a reduction in AEA, OEA, and DHEA after the testing period. In contrast, there were significant positive relationships between AEA, OEA, and DHEA vs. ppTG, ppApoCIII, and ppApoE in those consuming HFCS, but not in those consuming Asp. Our findings reveal previously unknown associations between circulating ECs and EC-related molecules with markers of lipid metabolism and CVD risk after HFCS consumption.
| Original language | English (US) |
|---|---|
| Pages (from-to) | E141-E149 |
| Journal | American Journal of Physiology - Endocrinology and Metabolism |
| Volume | 315 |
| Issue number | 2 |
| DOIs | |
| State | Published - Aug 1 2018 |
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Keywords
- Anandamide
- ApoCIII
- ApoE
- High-fructose corn syrup
- Oleoylethanolamide
- Triglycerides
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Physiology
- Physiology (medical)
Cite this
Plasma fatty acid ethanolamides are associated with postprandial triglycerides, ApoCIII, and ApoE in humans consuming a high-fructose corn syrup-sweetened beverage. / Price, Candice Allister; Argueta, Donovan A.; Medici, Valentina; Bremer, Andrew A.; Lee, Vivien; Nunez, Marinelle V.; Chen, Guoxia X.; Keim, Nancy L.; Havel, Peter J; Stanhope, Kimber; Dipatrizio, Nicholas V.
In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 315, No. 2, 01.08.2018, p. E141-E149.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Plasma fatty acid ethanolamides are associated with postprandial triglycerides, ApoCIII, and ApoE in humans consuming a high-fructose corn syrup-sweetened beverage
AU - Price, Candice Allister
AU - Argueta, Donovan A.
AU - Medici, Valentina
AU - Bremer, Andrew A.
AU - Lee, Vivien
AU - Nunez, Marinelle V.
AU - Chen, Guoxia X.
AU - Keim, Nancy L.
AU - Havel, Peter J
AU - Stanhope, Kimber
AU - Dipatrizio, Nicholas V.
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Epidemiological and clinical research studies have provided ample evidence demonstrating that consumption of sugar-sweetened beverages increases risk factors involved in the development of obesity, Type 2 diabetes, and cardiovascular disease (CVD). Our previous study demonstrated that when compared with aspartame (Asp), 2 wk of high-fructose corn syrup (HFCS)-sweetened beverages provided at 25% of daily energy requirement was associated with increased body weight, postprandial (pp) triglycerides (TG), and fasting and pp CVD risk factors in young adults. The fatty acid ethanolamide, anandamide (AEA), and the monoacylglycerol, 2-arachidonoyl-sn-glycerol (2-AG), are two primary endocannabinoids (ECs) that play a role in regulating food intake, increasing adipose storage, and regulating lipid metabolism. Therefore, we measured plasma concentrations of ECs and their analogs, oleoylethanolamide (OEA), docosahexaenoyl ethanolamide (DHEA), and docosahexaenoyl glycerol (DHG), in participants from our previous study who consumed HFCS-or Asp-sweetened beverages to determine associations with weight gain and CVD risk factors. Two-week exposure to either HFCS-or Asp-sweetened beverages resulted in significant differences in the changes in fasting levels of OEA and DHEA between groups after the testing period. Subjects who consumed Asp, but not HFCS, displayed a reduction in AEA, OEA, and DHEA after the testing period. In contrast, there were significant positive relationships between AEA, OEA, and DHEA vs. ppTG, ppApoCIII, and ppApoE in those consuming HFCS, but not in those consuming Asp. Our findings reveal previously unknown associations between circulating ECs and EC-related molecules with markers of lipid metabolism and CVD risk after HFCS consumption.
AB - Epidemiological and clinical research studies have provided ample evidence demonstrating that consumption of sugar-sweetened beverages increases risk factors involved in the development of obesity, Type 2 diabetes, and cardiovascular disease (CVD). Our previous study demonstrated that when compared with aspartame (Asp), 2 wk of high-fructose corn syrup (HFCS)-sweetened beverages provided at 25% of daily energy requirement was associated with increased body weight, postprandial (pp) triglycerides (TG), and fasting and pp CVD risk factors in young adults. The fatty acid ethanolamide, anandamide (AEA), and the monoacylglycerol, 2-arachidonoyl-sn-glycerol (2-AG), are two primary endocannabinoids (ECs) that play a role in regulating food intake, increasing adipose storage, and regulating lipid metabolism. Therefore, we measured plasma concentrations of ECs and their analogs, oleoylethanolamide (OEA), docosahexaenoyl ethanolamide (DHEA), and docosahexaenoyl glycerol (DHG), in participants from our previous study who consumed HFCS-or Asp-sweetened beverages to determine associations with weight gain and CVD risk factors. Two-week exposure to either HFCS-or Asp-sweetened beverages resulted in significant differences in the changes in fasting levels of OEA and DHEA between groups after the testing period. Subjects who consumed Asp, but not HFCS, displayed a reduction in AEA, OEA, and DHEA after the testing period. In contrast, there were significant positive relationships between AEA, OEA, and DHEA vs. ppTG, ppApoCIII, and ppApoE in those consuming HFCS, but not in those consuming Asp. Our findings reveal previously unknown associations between circulating ECs and EC-related molecules with markers of lipid metabolism and CVD risk after HFCS consumption.
KW - Anandamide
KW - ApoCIII
KW - ApoE
KW - High-fructose corn syrup
KW - Oleoylethanolamide
KW - Triglycerides
UR - http://www.scopus.com/inward/record.url?scp=85051295472&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85051295472&partnerID=8YFLogxK
U2 - 10.1152/ajpendo.00406.2017
DO - 10.1152/ajpendo.00406.2017
M3 - Article
C2 - 29634315
AN - SCOPUS:85051295472
VL - 315
SP - E141-E149
JO - American Journal of Physiology
JF - American Journal of Physiology
SN - 0193-1849
IS - 2
ER -