Abstract
A 40-year-old male with heterozygous familial hypercholesterolaemia was resistant to combined drug treatment with cholestyramine and nicotinic acid in adequate doses. He had angina pectoris and evidence of three vessel disease in the coronary angiogram. Repeated plasma exchange at intervals of 1-3 weeks simultaneously with combined drug treatment decreased the plasma cholesterol levels by nearly 40%. There were also signs of regression of xanthomata and some improvement of his angina pectoris. No progression of atherosclerosis was seen angiographically after two years of treatment. Plasma exchange may be a therapeutic alternative in drug-resistant familial hypercholesterolaemia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 317-320 |
| Number of pages | 4 |
| Journal | Acta Medica Scandinavica |
| Volume | 221 |
| Issue number | 3 |
| State | Published - 1987 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Internal Medicine
Cite this
Plasma exchange in a patient with heterozygous familial hypercholesterolaemia resistant to drug therapy. / Eriksson, M.; Lantz, B.; Berglund, Lars; Angelin, B.
In: Acta Medica Scandinavica, Vol. 221, No. 3, 1987, p. 317-320.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Plasma exchange in a patient with heterozygous familial hypercholesterolaemia resistant to drug therapy
AU - Eriksson, M.
AU - Lantz, B.
AU - Berglund, Lars
AU - Angelin, B.
PY - 1987
Y1 - 1987
N2 - A 40-year-old male with heterozygous familial hypercholesterolaemia was resistant to combined drug treatment with cholestyramine and nicotinic acid in adequate doses. He had angina pectoris and evidence of three vessel disease in the coronary angiogram. Repeated plasma exchange at intervals of 1-3 weeks simultaneously with combined drug treatment decreased the plasma cholesterol levels by nearly 40%. There were also signs of regression of xanthomata and some improvement of his angina pectoris. No progression of atherosclerosis was seen angiographically after two years of treatment. Plasma exchange may be a therapeutic alternative in drug-resistant familial hypercholesterolaemia.
AB - A 40-year-old male with heterozygous familial hypercholesterolaemia was resistant to combined drug treatment with cholestyramine and nicotinic acid in adequate doses. He had angina pectoris and evidence of three vessel disease in the coronary angiogram. Repeated plasma exchange at intervals of 1-3 weeks simultaneously with combined drug treatment decreased the plasma cholesterol levels by nearly 40%. There were also signs of regression of xanthomata and some improvement of his angina pectoris. No progression of atherosclerosis was seen angiographically after two years of treatment. Plasma exchange may be a therapeutic alternative in drug-resistant familial hypercholesterolaemia.
UR - http://www.scopus.com/inward/record.url?scp=0023213246&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023213246&partnerID=8YFLogxK
M3 - Article
C2 - 3591471
AN - SCOPUS:0023213246
VL - 221
SP - 317
EP - 320
JO - Journal of Internal Medicine
JF - Journal of Internal Medicine
SN - 0954-6820
IS - 3
ER -