Plasma exchange in a patient with heterozygous familial hypercholesterolaemia resistant to drug therapy

M. Eriksson, B. Lantz, Lars Berglund, B. Angelin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A 40-year-old male with heterozygous familial hypercholesterolaemia was resistant to combined drug treatment with cholestyramine and nicotinic acid in adequate doses. He had angina pectoris and evidence of three vessel disease in the coronary angiogram. Repeated plasma exchange at intervals of 1-3 weeks simultaneously with combined drug treatment decreased the plasma cholesterol levels by nearly 40%. There were also signs of regression of xanthomata and some improvement of his angina pectoris. No progression of atherosclerosis was seen angiographically after two years of treatment. Plasma exchange may be a therapeutic alternative in drug-resistant familial hypercholesterolaemia.

Original languageEnglish (US)
Pages (from-to)317-320
Number of pages4
JournalActa Medica Scandinavica
Volume221
Issue number3
StatePublished - 1987
Externally publishedYes

Fingerprint

Hyperlipoproteinemia Type II
Plasma Exchange
Drug Therapy
Angina Pectoris
Pharmaceutical Preparations
Cholestyramine Resin
Xanthomatosis
Niacin
Therapeutics
Coronary Disease
Atherosclerosis
Angiography
Cholesterol

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Plasma exchange in a patient with heterozygous familial hypercholesterolaemia resistant to drug therapy. / Eriksson, M.; Lantz, B.; Berglund, Lars; Angelin, B.

In: Acta Medica Scandinavica, Vol. 221, No. 3, 1987, p. 317-320.

Research output: Contribution to journalArticle

@article{e0b3c94f43f74d929db164fff5443532,
title = "Plasma exchange in a patient with heterozygous familial hypercholesterolaemia resistant to drug therapy",
abstract = "A 40-year-old male with heterozygous familial hypercholesterolaemia was resistant to combined drug treatment with cholestyramine and nicotinic acid in adequate doses. He had angina pectoris and evidence of three vessel disease in the coronary angiogram. Repeated plasma exchange at intervals of 1-3 weeks simultaneously with combined drug treatment decreased the plasma cholesterol levels by nearly 40{\%}. There were also signs of regression of xanthomata and some improvement of his angina pectoris. No progression of atherosclerosis was seen angiographically after two years of treatment. Plasma exchange may be a therapeutic alternative in drug-resistant familial hypercholesterolaemia.",
author = "M. Eriksson and B. Lantz and Lars Berglund and B. Angelin",
year = "1987",
language = "English (US)",
volume = "221",
pages = "317--320",
journal = "Journal of Internal Medicine",
issn = "0954-6820",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Plasma exchange in a patient with heterozygous familial hypercholesterolaemia resistant to drug therapy

AU - Eriksson, M.

AU - Lantz, B.

AU - Berglund, Lars

AU - Angelin, B.

PY - 1987

Y1 - 1987

N2 - A 40-year-old male with heterozygous familial hypercholesterolaemia was resistant to combined drug treatment with cholestyramine and nicotinic acid in adequate doses. He had angina pectoris and evidence of three vessel disease in the coronary angiogram. Repeated plasma exchange at intervals of 1-3 weeks simultaneously with combined drug treatment decreased the plasma cholesterol levels by nearly 40%. There were also signs of regression of xanthomata and some improvement of his angina pectoris. No progression of atherosclerosis was seen angiographically after two years of treatment. Plasma exchange may be a therapeutic alternative in drug-resistant familial hypercholesterolaemia.

AB - A 40-year-old male with heterozygous familial hypercholesterolaemia was resistant to combined drug treatment with cholestyramine and nicotinic acid in adequate doses. He had angina pectoris and evidence of three vessel disease in the coronary angiogram. Repeated plasma exchange at intervals of 1-3 weeks simultaneously with combined drug treatment decreased the plasma cholesterol levels by nearly 40%. There were also signs of regression of xanthomata and some improvement of his angina pectoris. No progression of atherosclerosis was seen angiographically after two years of treatment. Plasma exchange may be a therapeutic alternative in drug-resistant familial hypercholesterolaemia.

UR - http://www.scopus.com/inward/record.url?scp=0023213246&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023213246&partnerID=8YFLogxK

M3 - Article

C2 - 3591471

AN - SCOPUS:0023213246

VL - 221

SP - 317

EP - 320

JO - Journal of Internal Medicine

JF - Journal of Internal Medicine

SN - 0954-6820

IS - 3

ER -