Plasma exchange in a patient with heterozygous familial hypercholesterolaemia resistant to drug therapy

M. Eriksson, B. Lantz, Lars Berglund, B. Angelin

Research output: Contribution to journalArticle

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A 40-year-old male with heterozygous familial hypercholesterolaemia was resistant to combined drug treatment with cholestyramine and nicotinic acid in adequate doses. He had angina pectoris and evidence of three vessel disease in the coronary angiogram. Repeated plasma exchange at intervals of 1-3 weeks simultaneously with combined drug treatment decreased the plasma cholesterol levels by nearly 40%. There were also signs of regression of xanthomata and some improvement of his angina pectoris. No progression of atherosclerosis was seen angiographically after two years of treatment. Plasma exchange may be a therapeutic alternative in drug-resistant familial hypercholesterolaemia.

Original languageEnglish (US)
Pages (from-to)317-320
Number of pages4
JournalActa Medica Scandinavica
Issue number3
StatePublished - 1987
Externally publishedYes


ASJC Scopus subject areas

  • Internal Medicine

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