Plasma cytokines and oxidative damage in HIV-positive and HIV-negative adolescents and young adults: A protective role for IL-10?

Charles B. Stephensen, Grace S. Marquis, Steven D. Douglas, Craig M. Wilson

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

HIV infection causes immune activation that leads to oxidative damage. Proinflammatory cytokines may promote such damage and the regulatory cytokine IL-10 may protect against such damage. To examine the relation of these cytokines to oxidative damage, 67 cases of oxidative damage and 67 matched controls were selected from the reaching for excellence in adolescent health (REACH) study. Subjects were young (15-23 years), largely female (76%), HIV-positive (73%) and black (69%). Proinflammatory cytokines were not significantly associated with oxidative damage but plasma IL-10 had a significant, negative association with oxidative damage. This finding is consistent with a protective role for IL-10 in diminishing oxidative damage during immune activation.

Original languageEnglish (US)
Pages (from-to)859-864
Number of pages6
JournalFree Radical Research
Volume39
Issue number8
DOIs
StatePublished - Aug 2005

Keywords

  • HIV
  • IL-10
  • Malondialdehyde
  • Oxidative damage
  • Protein carbonyl

ASJC Scopus subject areas

  • Biochemistry

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