Plasma cytokines and oxidative damage in HIV-positive and HIV-negative adolescents and young adults: A protective role for IL-10?

Charles B. Stephensen, Grace S. Marquis, Steven D. Douglas, Craig M. Wilson

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

HIV infection causes immune activation that leads to oxidative damage. Proinflammatory cytokines may promote such damage and the regulatory cytokine IL-10 may protect against such damage. To examine the relation of these cytokines to oxidative damage, 67 cases of oxidative damage and 67 matched controls were selected from the reaching for excellence in adolescent health (REACH) study. Subjects were young (15-23 years), largely female (76%), HIV-positive (73%) and black (69%). Proinflammatory cytokines were not significantly associated with oxidative damage but plasma IL-10 had a significant, negative association with oxidative damage. This finding is consistent with a protective role for IL-10 in diminishing oxidative damage during immune activation.

Original languageEnglish (US)
Pages (from-to)859-864
Number of pages6
JournalFree Radical Research
Volume39
Issue number8
DOIs
StatePublished - Aug 2005

Fingerprint

Interleukin-10
Young Adult
HIV
Cytokines
Plasmas
Chemical activation
HIV Infections
Health
Association reactions

Keywords

  • HIV
  • IL-10
  • Malondialdehyde
  • Oxidative damage
  • Protein carbonyl

ASJC Scopus subject areas

  • Biochemistry

Cite this

Plasma cytokines and oxidative damage in HIV-positive and HIV-negative adolescents and young adults : A protective role for IL-10? / Stephensen, Charles B.; Marquis, Grace S.; Douglas, Steven D.; Wilson, Craig M.

In: Free Radical Research, Vol. 39, No. 8, 08.2005, p. 859-864.

Research output: Contribution to journalArticle

Stephensen, Charles B. ; Marquis, Grace S. ; Douglas, Steven D. ; Wilson, Craig M. / Plasma cytokines and oxidative damage in HIV-positive and HIV-negative adolescents and young adults : A protective role for IL-10?. In: Free Radical Research. 2005 ; Vol. 39, No. 8. pp. 859-864.
@article{0dc5201dcb614464b45aac0903365945,
title = "Plasma cytokines and oxidative damage in HIV-positive and HIV-negative adolescents and young adults: A protective role for IL-10?",
abstract = "HIV infection causes immune activation that leads to oxidative damage. Proinflammatory cytokines may promote such damage and the regulatory cytokine IL-10 may protect against such damage. To examine the relation of these cytokines to oxidative damage, 67 cases of oxidative damage and 67 matched controls were selected from the reaching for excellence in adolescent health (REACH) study. Subjects were young (15-23 years), largely female (76{\%}), HIV-positive (73{\%}) and black (69{\%}). Proinflammatory cytokines were not significantly associated with oxidative damage but plasma IL-10 had a significant, negative association with oxidative damage. This finding is consistent with a protective role for IL-10 in diminishing oxidative damage during immune activation.",
keywords = "HIV, IL-10, Malondialdehyde, Oxidative damage, Protein carbonyl",
author = "Stephensen, {Charles B.} and Marquis, {Grace S.} and Douglas, {Steven D.} and Wilson, {Craig M.}",
year = "2005",
month = "8",
doi = "10.1080/10715760500164136",
language = "English (US)",
volume = "39",
pages = "859--864",
journal = "Free Radical Research",
issn = "1071-5762",
publisher = "Informa Healthcare",
number = "8",

}

TY - JOUR

T1 - Plasma cytokines and oxidative damage in HIV-positive and HIV-negative adolescents and young adults

T2 - A protective role for IL-10?

AU - Stephensen, Charles B.

AU - Marquis, Grace S.

AU - Douglas, Steven D.

AU - Wilson, Craig M.

PY - 2005/8

Y1 - 2005/8

N2 - HIV infection causes immune activation that leads to oxidative damage. Proinflammatory cytokines may promote such damage and the regulatory cytokine IL-10 may protect against such damage. To examine the relation of these cytokines to oxidative damage, 67 cases of oxidative damage and 67 matched controls were selected from the reaching for excellence in adolescent health (REACH) study. Subjects were young (15-23 years), largely female (76%), HIV-positive (73%) and black (69%). Proinflammatory cytokines were not significantly associated with oxidative damage but plasma IL-10 had a significant, negative association with oxidative damage. This finding is consistent with a protective role for IL-10 in diminishing oxidative damage during immune activation.

AB - HIV infection causes immune activation that leads to oxidative damage. Proinflammatory cytokines may promote such damage and the regulatory cytokine IL-10 may protect against such damage. To examine the relation of these cytokines to oxidative damage, 67 cases of oxidative damage and 67 matched controls were selected from the reaching for excellence in adolescent health (REACH) study. Subjects were young (15-23 years), largely female (76%), HIV-positive (73%) and black (69%). Proinflammatory cytokines were not significantly associated with oxidative damage but plasma IL-10 had a significant, negative association with oxidative damage. This finding is consistent with a protective role for IL-10 in diminishing oxidative damage during immune activation.

KW - HIV

KW - IL-10

KW - Malondialdehyde

KW - Oxidative damage

KW - Protein carbonyl

UR - http://www.scopus.com/inward/record.url?scp=22144442472&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22144442472&partnerID=8YFLogxK

U2 - 10.1080/10715760500164136

DO - 10.1080/10715760500164136

M3 - Article

C2 - 16036366

AN - SCOPUS:22144442472

VL - 39

SP - 859

EP - 864

JO - Free Radical Research

JF - Free Radical Research

SN - 1071-5762

IS - 8

ER -