Plasma biomarkers of astrocytic and neuronal dysfunction in early- and late-onset Alzheimer's disease

Fanny M. Elahi, Kaitlin B. Casaletto, Renaud La Joie, Samantha M. Walters, Danielle Harvey, Amy Wolf, Lauren Edwards, Wilfredo Rivera-Contreras, Anna Karydas, Yann Cobigo, Howard J. Rosen, Charles DeCarli, Bruce L. Miller, Gil D. Rabinovici, Joel H. Kramer

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Introduction: We investigated plasma proteomic markers of astrocytopathy, brain degeneration, plasticity, and inflammation in sporadic early-onset versus late-onset Alzheimer's disease (EOAD and LOAD). Methods: Plasma was analyzed using ultra-sensitive immuno-based assays from 33 EOAD, 30 LOAD, and 36 functionally normal older adults. Results: Principle component analyses identified 3 factors: trophic (BDNF, VEGF, TGFβ), degenerative (GFAP, NfL), and inflammatory (TNFα, IL-6, IP-10, IL-10). Trophic factor was elevated in both AD groups and associated with cognition and gray matter volumes. Degenerative factor was elevated in EOAD, with higher levels associated with worse functioning in this group. Biomarkers of inflammation were not significantly different between groups and were only associated with age. Disucssion: Plasma proteomic biomarkers provide novel means of investigating molecular processes in vivo and their contributions to clinical outcomes. We present initial investigations of several of these fluid biomarkers, capturing aspects of astrocytopathy, neuronal injury, cellular plasticity, and inflammation in EOAD versus LOAD.

Original languageEnglish (US)
JournalAlzheimer's and Dementia
DOIs
StateAccepted/In press - Jan 1 2019

Keywords

  • Astrocytopathy
  • Brain homeostasis
  • Cerebral small vessel disease
  • Early-onset Alzheimer's disease
  • Exosomes
  • Growth hormones
  • Immune activation
  • Inflammation
  • Late-onset Alzheimer's disease
  • Neurodegeneration
  • White matter disease

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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